Abstract: The functional role of the respiratory epithelium is to generate a physical barrier. In addition, the epithelium supports the innate and acquired immune system through various cytokines and chemokines. However, epithelial cells are also involved in the pathogenesis of various respiratory diseases, some of which are mediated by increased permeability of the mucosal membrane or disturbed mucociliary transport. In addition, it has been shown that epithelial cells are involved in the development of inflammatory respiratory diseases. The following review article focuses on the aspects of epithelial mis-differentiation, in particular with respect to nasal mucosal barrier function, epithelial immunogenicity, nasal epithelial–mesenchymal transition and nasal microbiome.

Keywords: nasal mucosal barrier function, tight junction, epithelial–mesenchymal transition, microbiome


中文翻译：

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鼻上皮细胞误分化的最新认识

摘要：呼吸道上皮的功能作用是产生物理屏障。另外，上皮通过各种细胞因子和趋化因子支持先天和后天免疫系统。然而，上皮细胞也参与了各种呼吸系统疾病的发病机制，其中一些是由粘膜渗透性增加或粘膜纤毛运输受阻所介导的。另外，已经显示上皮细胞参与炎性呼吸系统疾病的发展。以下评论文章着重于上皮误分化方面，特别是关于鼻粘膜屏障功能，上皮免疫原性，鼻上皮-间质转化和鼻腔微生物组。

关键字： 鼻粘膜屏障功能，紧密连接，上皮-间质转化，微生物组