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Exosomal miR‐663b targets Ets2‐repressor factor to promote proliferation and the epithelial–mesenchymal transition of bladder cancer cells
Cell Biology International ( IF 3.9 ) Pub Date : 2020-01-06 , DOI: 10.1002/cbin.11292
Xinbao Yin 1 , Xueping Zheng 2 , Ming Liu 1 , Dong Wang 1 , Hui Sun 1 , Yue Qiu 1 , Jun Chen 1 , Benkang Shi 3
Affiliation  

Exosomes circulating in biological fluids have the potential to be utilized as cancer biomarkers and are associated with cancer progression and metastasis. MicroRNA (miR)‐663b has been found to be elevated in plasma from patients with bladder cancer (BC). However, the functional role of exosomal miR‐663b in BC processes remains unknown. Here, we isolated exosomes from plasma and found that the miR‐663b level was elevated in exosomes from plasma of patients with BC compared with healthy controls. Exosomal miR‐663b from BC cells promoted cell proliferation and epithelial–mesenchymal transition. Moreover, exosomal miR‐663b targeted Ets2‐repressor factor and acted as a tumor promoter in BC cells. Taken together, our findings suggested that exosomal miR‐663b is a promising potential biomarker and target for clinical detection and therapy in BC.

中文翻译:

外泌体miR-663b靶向Ets2-阻遏因子,以促进膀胱癌细胞的增殖和上皮-间质转化

在生物体液中循环的外来体有可能被用作癌症生物标志物,并与癌症的进展和转移有关。已发现患有膀胱癌(BC)的患者血浆中的MicroRNA(miR)‐663b升高。然而,外泌体miR-663b在BC过程中的功能作用仍然未知。在这里,我们从血浆中分离出外泌体,发现与健康对照组相比,BC患者血浆的外泌体中的miR‐663b水平升高。BC细胞的外泌体miR‐663b促进细胞增殖和上皮-间质转化。此外,外泌体miR-663b靶向Ets2-阻遏因子,并在BC细胞中充当肿瘤启动子。综上所述,我们的研究结果表明,外泌体miR‐663b是有前途的潜在生物标志物,是BC临床检测和治疗的目标。
更新日期:2020-04-13
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