Metabolic bone diseases are a group of conditions that are common complications in patients with intestinal failure. These may occur as a result of the underlying condition, leading to intestinal failure, particularly inflammatory conditions such as Crohn’s disease and their associated treatments including corticosteroids. Malabsorption, as a result of a loss of enterocyte mass or gut function, of many nutrients, including vitamin D, may further compound metabolic bone problems, and there has been historical contamination of parenteral nutrition with aluminium that has prevented normal bone metabolism contributing to osteoporosis. This review looks at the diagnosis and current management of bone health in patients with intestinal failure.

中文翻译：

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肠道代谢性骨疾病。

代谢性骨疾病是肠道衰竭患者常见的并发症。这些可能是由于潜在疾病导致的，导致肠道衰竭，尤其是炎症性疾病，例如克罗恩氏病及其相关治疗，包括皮质类固醇。由于肠上皮细胞质量或肠道功能的丧失，许多营养素（包括维生素D）吸收不良可能会进一步加剧新陈代谢的骨骼问题，并且铝对肠胃外营养的污染已有历史记录，阻止了正常的骨骼代谢，从而导致骨质疏松。这篇综述着眼于肠衰竭患者的骨骼健康诊断和当前管理。