The N-protected cis-4-aminocyclohexanol derivatives have proven to be valuable intermediates in the syntheses of active pharmaceutical ingredients (APIs). A novel continuous flow process for hydrogenation of N-protected 2-oxa-3-azabicyclo[2.2.2]oct-5-ene cycloadducts to the corresponding cis-4-aminocyclohexanols has been reported using H-Cube Pro. A > 99% selectivity towards the desired product was obtained using Raney nickel catalyst cartridge. Under carefully selected hydrogenation parameters the reduction could stop at the also valuable 2-oxa-3-azabicyclo[2.2.2] octane intermediate, with a selectivity of >99%. The N-protected 2-oxa-3-azabicyclo[2.2.2]oct-5-ene producing nitroso hetero-Diels–Alder cycloaddition was also accomplished in a flow system using an Omnifit column packed with MnO₂. The two flow reactions were successfully merged in a system, thus the product was obtained in a multistep flow synthesis without any isolation or purification steps. Compared with the previously reported batch processes, the present multistep procedure facilitates an efficient cis selective preparation of numerous synthetically valuable 4-aminocyclohexanol derivatives.

的Ñ -保护的顺式-4-氨基环己醇的衍生物已被证明是在活性药物成分（API）的合成有价值的中间体。已经报道了使用H-Cube Pro将N-保护的2-氧杂-3-氮杂双环[2.2.2]辛-5-烯环加合物氢化成相应的顺式-4-氨基环己醇的新颖连续流程。使用阮内镍催化剂盒获得对所需产物的＞ 99％的选择性。在精心选择的氢化参数下，还原反应可以在有价值的2-氧杂-3-氮杂双环[2.2.2]辛烷中间体处停止，选择性> 99％。该ñ使用填充了MnO ₂的Omnifit色谱柱在流动系统中也完成了保护性的2-oxa-3-azabicyclo [2.2.2] oct-5-ene生成亚硝基杂Diels-Alder环加成反应。两种流动反应在系统中成功合并，因此无需任何分离或纯化步骤，即可通过多步流动合成获得产物。与先前报道的间歇方法相比，本发明的多步骤方法促进了许多合成上有价值的4-氨基环己醇衍生物的高效顺式选择性制备。