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Physical Activity Ameliorates Impaired Hippocampal Neurogenesis in the Tg4-42 Mouse Model of Alzheimer's Disease.
ASN Neuro ( IF 4.7 ) Pub Date : 2019-12-09 , DOI: 10.1177/1759091419892692
Anna-Lina Gerberding 1 , Silvia Zampar 1 , Martina Stazi 1 , David Liebetanz 2 , Oliver Wirths 1
Affiliation  

Alzheimer’s disease (AD) is the most common form of dementia. There is accumulating evidence that in addition to genetics, other lifestyle and environmental factors may have a share in the individual risk of getting AD, which opens new opportunities for prevention (Mattson, 2015). Risk factors include diabetes mellitus, midlife obesity and hypertension, smoking, depression and dyslipidemia (Mayeux and Stern, 2012), and many of these factors are considered potentially modifiable (Livingston et al., 2017). Physical activity has especially been associated with a reduced dementia risk in a variety of epidemiological studies (Scarmeas et al., 2001; Santos-Lozano et al., 2016) and has been recently shown to exert beneficial effects on cognition and AD pathology, even in individuals with genetically driven autosomal dominant AD (Müller et al., 2018). It has been predicted that ∼13% of AD cases can be attributed to physical inactivity and that a 25% reduction in physical inactivity has the potential to prevent nearly 1 million cases worldwide (Barnes and Yaffe, 2011).

中文翻译:

体力活动可改善阿尔茨海默氏病Tg4-42小鼠模型中海马神经发生受损。

阿尔茨海默氏病(AD)是痴呆症的最常见形式。有越来越多的证据表明,除了遗传因素外,其他生活方式和环境因素也可能与个体患AD的风险有关,这为预防提供了新的机会(Mattson,2015)。危险因素包括糖尿病,中年肥胖和高血压,吸烟,抑郁和血脂异常(Mayeux和Stern,2012),其中许多因素被认为具有潜在的可变性(Livingston等,2017)。在各种流行病学研究中,体育活动尤其与痴呆症风险降低相关(Scarmeas等,2001; Santos-Lozano等,2016),最近已证明,体育锻炼可对认知和AD病理产生有益的影响,甚至具有基因驱动的常染色体显性AD的个体(Müller等,2018)。
更新日期:2020-04-20
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