Abstract

This review summarizes the main achievements of recent years in molecular organization research of yeast cell surface, i.e., the compartment that consists of the coordinately functioning plasma membrane, periplasmic space, and cell wall. There are data on vesicular transport to the external environment through the cell wall and the formation of channels in the wall, which indicate the possibility of dynamic rearrangements of the molecular structure of the yeast cell wall. There is an idea about the mosaic arrangement of the compartments of the plasma membrane. The hypothesis has been suggested on the heterogeneity of the molecular structure of the cell wall, which is usually considered as uniform except for the budding zones. The groups of proteins that form the molecular assembly of the yeast cell surface have been described. Special attention has been paid for proteins with amyloid properties, including Bgl2p glucanosyltransglycosylase, which is important for virulence in pathogenic yeast, and Gas1p, the first of the studied proteins of the cell surface, which is involved in the regulation of ribosomal DNA transcriptional silencing. The data on the structure of receptors localized on the cell surface and the “moonlight” proteins, involved in the cell stress response of yeasts, have been given.

中文翻译：

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酵母细胞包膜的分子组织

摘要

这篇综述总结了近年来酵母细胞表面分子组织研究的主要成果，即由协调功能的质膜，周质空间和细胞壁组成的隔室。有关于通过细胞壁将囊泡转运到外部环境和壁中通道形成的数据，这表明酵母细胞壁分子结构动态重排的可能性。关于质膜隔室的镶嵌布置有一个想法。已经提出了关于细胞壁分子结构的异质性的假说，该结构通常被认为是一致的，除了萌芽区。已经描述了形成酵母细胞表面分子装配的蛋白质组。对具有淀粉样蛋白特性的蛋白质给予了特别的关注，其中包括对致病酵母中的毒力很重要的Bgl2p葡糖基糖基转糖基化酶，以及研究细胞表面蛋白质的第一个Gas1p，它参与了核糖体DNA转录沉默的调控。已经给出了位于细胞表面的受体结构和参与酵母细胞应激反应的“月光”蛋白的数据。