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Understanding neurobehavioral genetics of zebrafish
Journal of Neurogenetics ( IF 1.9 ) Pub Date : 2020-01-05 , DOI: 10.1080/01677063.2019.1698565
Sergey V Cheresiz 1, 2 , Andrey D Volgin 1, 2 , Alexandra Kokorina Evsyukova 1, 2 , Alim A O Bashirzade 1, 2 , Konstantin A Demin 3, 4 , Murilo S de Abreu 5, 6 , Tamara G Amstislavskaya 1, 2, 6 , Allan V Kalueff 7, 8, 9, 10
Affiliation  

Due to its fully sequenced genome, high genetic homology to humans, external fertilization, fast development, transparency of embryos, low cost and active reproduction, the zebrafish (Danio rerio) has become a novel promising model organism in biomedicine. Zebrafish are a useful tool in genetic and neuroscience research, including linking various genetic mutations to brain mechanisms using forward and reverse genetics. These approaches have produced novel models of rare genetic CNS disorders and common brain illnesses, such as addiction, aggression, anxiety and depression. Genetically modified zebrafish also foster neuroanatomical studies, manipulating neural circuits and linking them to different behaviors. Here, we discuss recent advances in neurogenetics of zebrafish, and evaluate their unique strengths, inherent limitations and the rapidly growing potential for elucidating the conserved roles of genes in neuropsychiatric disorders.



中文翻译:

了解斑马鱼的神经行为遗传学

由于其全基因组序列,与人类的高度遗传同源性,外部受精,快速发育,胚胎透明,低成本和活跃繁殖,斑马鱼(斑马鱼)在生物医学中已成为一种有希望的新型模式生物。斑马鱼是遗传和神经科学研究的有用工具,包括使用正向和反向遗传学将各种遗传突变与大脑机制联系起来。这些方法产生了罕见的遗传性中枢神经系统疾病和常见的脑部疾病,例如成瘾,攻击性,焦虑和抑郁的新颖模型。转基因的斑马鱼还促进了神经解剖学研究,操纵神经回路并将它们与不同的行为联系起来。在这里,我们讨论了斑马鱼神经遗传学的最新进展,并评估了它们的独特优势,内在局限性以及阐明基因在神经精神疾病中的保守作用的迅速增长的潜力。

更新日期:2020-01-05
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