A transcriptional program implemented by transcription factors and epigenetic regulators governs cardiac development and disease. Mutations in these factors are important causes of congenital heart disease. Here, we review selected recent advances in our understanding of the transcriptional and epigenetic control of heart development, including determinants of cardiac transcription factor chromatin occupancy, the gene regulatory network that regulates atrial septation, the chromatin landscape and cardiac gene regulation, and the role of Brg/Brahma-associated factor (BAF), nucleosome remodeling and histone deacetylation (NuRD), and Polycomb epigenetic regulatory complexes in heart development.

中文翻译：

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心脏发育的遗传和表观遗传控制。

由转录因子和表观遗传调节剂实施的转录程序控制心脏发育和疾病。这些因素的突变是导致先天性心脏病的重要原因。在这里，我们回顾了我们对心脏发育的转录和表观遗传控制的理解的最新进展，包括心脏转录因子染色质占据的决定因素、调节心房间隔的基因调控网络、染色质景观和心脏基因调控，以及Brg/Brahma 相关因子 (BAF)、核小体重塑和组蛋白去乙酰化 (NuRD) 以及心脏发育中的 Polycomb 表观遗传调控复合物。