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Sonochemical Decoration of Graphene Oxide with Magnetic Fe3O4@CuO Nanocomposite for Efficient Click Synthesis of Coumarin-Sugar Based Bioconjugates and Their Cytotoxic Activity
Catalysis Letters ( IF 2.8 ) Pub Date : 2019-10-14 , DOI: 10.1007/s10562-019-02982-6
Yachana Jain , Mitlesh Kumari , Raman Preet Singh , Deepak Kumar , Ragini Gupta

A magnetic nanocomposite of GO-Fe3O4@CuO was fabricated via a simple sonochemical technique and successfully utilized for the ultrasound promoted synthesis of regioselective 1,4-disubstituted mono/bis/tris-1,2,3-triazoles (3a–k). This catalyst could be separated conveniently from the reaction mixture using an external magnet and reused up to eight consecutive runs without noticeable drop in the desired product yield. Other noteworthy features of this green protocol are negligible metal leaching from the support during reaction, high yield in lesser time, aqueous media and good results with gram scale synthesis. Representative compounds were also screened for their cytotoxic activity against PC-12 cell line using standard MTT assay and flow cytometry. Trifluoromethyl group containing triazole derivative (3f) displayed cytotoxic activity (IC50 8.3 µg/mL) comparable to the standard drug cisplatin (IC50 5.8 µg/mL).

中文翻译:

用磁性 Fe3O4@CuO 纳米复合材料对氧化石墨烯进行声化学修饰,用于有效点击合成香豆素-糖基生物共轭物及其细胞毒活性

通过简单的声化学技术制备了 GO-Fe3O4@CuO 磁性纳米复合材料,并成功用于区域选择性 1,4-二取代单/双/三-1,2,3-三唑(3a-k)的超声促进合成。这种催化剂可以使用外部磁铁方便地从反应混合物中分离出来,并且可以重复使用最多八次连续运行,而所需的产物产率没有明显下降。这种绿色协议的其他值得注意的特点是在反应过程中从载体中浸出的金属可以忽略不计,在较短的时间内产量高,水介质和克级合成的良好结果。还使用标准 MTT 分析和流式细胞术筛选了代表性化合物对 PC-12 细胞系的细胞毒活性。含有三氟甲基的三唑衍生物 (3f) 显示出细胞毒活性 (IC50 8.
更新日期:2019-10-14
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