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Printability study of metal ion crosslinked PEG-catechol based inks.
Biofabrication ( IF 9 ) Pub Date : 2020-04-29 , DOI: 10.1088/1758-5090/ab673a Małgorzata K Włodarczyk-Biegun 1 , Julieta I Paez , Maria Villiou , Jun Feng , Aranzazu Del Campo
Biofabrication ( IF 9 ) Pub Date : 2020-04-29 , DOI: 10.1088/1758-5090/ab673a Małgorzata K Włodarczyk-Biegun 1 , Julieta I Paez , Maria Villiou , Jun Feng , Aranzazu Del Campo
Affiliation
In this paper we explore the printability of reversible networks formed by catechol functionalized PEG solutions and metal cations (Al3+, Fe3+ or V3+). The printability and shape fidelity were dependent on the ink composition (metal ion type, pH, PEG molecular weight) and printing parameters (extrusion pressure and printing speed). The relaxation time, recovery rate and viscosity of the inks were analyzed in rheology studies and correlated with thermodynamic and ligand exchange kinetic constants of the dynamic bonds and the printing performance (i.e. shape fidelity of the printed structures). The relevance of the relaxation time and ligand exchange kinetics for printability was demonstrated. Cells seeded on the materials crosslinked with Al3+, Fe3+ ions were viable and revealed well-spread morphologies during 7 day culture, indicating the potential of the formulations to be used as inks for cell encapsulation. The proposed dynamic ink design offers significant flexibility for 3D bioprinting, and enables straightforward adjustment of the printable formulation to meet application-specific needs.
中文翻译:
金属离子交联的PEG-邻苯二酚基油墨的可印刷性研究。
在本文中,我们探讨了由邻苯二酚官能化的PEG溶液和金属阳离子(Al3 +,Fe3 +或V3 +)形成的可逆网络的可印刷性。可印刷性和形状保真度取决于油墨组成(金属离子类型,pH,PEG分子量)和印刷参数(挤出压力和印刷速度)。在流变学研究中分析了油墨的弛豫时间,恢复率和粘度,并将其与动态键的热力学和配体交换动力学常数以及印刷性能(即印刷结构的形状保真度)相关联。证明了弛豫时间和配体交换动力学与可印刷性的相关性。接种在与Al3 +,Fe3 +离子交联的材料上的细胞是可行的,并在7天的培养过程中表现出良好的形态分布,表明制剂可用作细胞包封油墨的潜力。所提出的动态墨水设计为3D生物打印提供了显着的灵活性,并能够直接调整可打印配方以满足特定应用的需求。
更新日期:2020-04-28
中文翻译:
金属离子交联的PEG-邻苯二酚基油墨的可印刷性研究。
在本文中,我们探讨了由邻苯二酚官能化的PEG溶液和金属阳离子(Al3 +,Fe3 +或V3 +)形成的可逆网络的可印刷性。可印刷性和形状保真度取决于油墨组成(金属离子类型,pH,PEG分子量)和印刷参数(挤出压力和印刷速度)。在流变学研究中分析了油墨的弛豫时间,恢复率和粘度,并将其与动态键的热力学和配体交换动力学常数以及印刷性能(即印刷结构的形状保真度)相关联。证明了弛豫时间和配体交换动力学与可印刷性的相关性。接种在与Al3 +,Fe3 +离子交联的材料上的细胞是可行的,并在7天的培养过程中表现出良好的形态分布,表明制剂可用作细胞包封油墨的潜力。所提出的动态墨水设计为3D生物打印提供了显着的灵活性,并能够直接调整可打印配方以满足特定应用的需求。