Ipomoea mauritiana is one of the source plants of Vidari, an Ayurvedic drug used as Medhyarasayana (rejuvenating drug). In this current study, coumarins were separated from tuberous root of I. mauritiana and characterization of the coumarin fraction was done by LC-MS/MS analysis by atmospheric pressure chemical ionization method. Anti-amnesic activity was evaluated against scopolamine induced amnesia in Wistar rats. Mass spectroscopic characterization of coumarin fraction directed to the tentative identification of coumarins such as 7-hydroxy-6-methoxy coumarin, 7-hydroxycoumarin, 5-methoxy-6,7-furanocoumarin, 5,7-dimethoxycoumarin, and 6-hydroxy-7-methoxy-4-phenylcoumarin. Aqueous extract of I. mauritiana at a dose of 100 and 200 mg/kg showed significant anti-amnesic activity against scopolamine-induced changes in step through latency and working memory errors. The findings of the study showed that I. mauritiana is a rich source of coumarins and possessed significant anti-amnesic activity. The study concluded the scientific basis of using I. mauritiana as rejuvenating drug in Ayurveda.

中文翻译：

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通过 LC-APCI-MS/MS 分析表征毛里求斯番薯中的香豆素并评估其抗遗忘活性

Ipomoea mauritiana 是 Vidari 的来源植物之一，Vidari 是一种阿育吠陀药物，用作 Medhyarasayana（恢复活力的药物）。在当前的这项研究中，香豆素从毛里求斯的块根中分离出来，香豆素部分的表征是通过大气压化学电离方法的 LC-MS/MS 分析完成的。在 Wistar 大鼠中针对东莨菪碱诱导的健忘症评估了抗健忘症活性。香豆素组分的质谱表征旨在初步鉴定香豆素，例如 7-羟基-6-甲氧基香豆素、7-羟基香豆素、5-甲氧基-6,7-呋喃香豆素、5,7-二甲氧基香豆素和 6-羟基-7 -甲氧基-4-苯基香豆素。I 的水提取物。mauritiana 在 100 和 200 毫克/千克的剂量下显示出显着的抗遗忘活性，对抗东莨菪碱诱导的潜伏期和工作记忆错误的变化。研究结果表明，毛里求斯毛里求斯富含香豆素，具有显着的抗遗忘活性。该研究总结了在阿育吠陀中使用毛里求斯毛里求斯作为振兴药物的科学基础。