Nitrogen atom containing heterocycles showed diverse biological properties are important structural feature of many physiologically active compounds. Pyridazines and phthalazines hold considerable interest relative to the preparation of physiologically active compounds. The pyridazine compounds also show antifeeedant, insecticidal, herbicidal, molluscicidal, plant growth regulatory and other agrochemical activities. The various pyridazine drugs are selective PDE-III inhibitors possessed positive inotropic effect combined with vasodilation. These agents are effective in different cardiovascular diseases like acute and chronic heart failure, myocardial infarction, angina, arrhythmia, and hypertension. Pyridazines and phthalazines further focus our attention because of their easy functionalization at various ring positions, which makes them attractive synthetic compounds for designing and development of the novel pyridazines and phthalazines drugs in future. Various substituted pyridazine derivatives were also reported to show antibacterial, antifungal, and antiviral properties. We considered some compounds bearing pyridazine in their molecular framework.

中文翻译：

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多种生物活性哒嗪类似物：高度官能化的杂环化合物的支架。

含氮原子的杂环显示出多种生物学特性，是许多生理活性化合物的重要结构特征。哒嗪和酞嗪相对于生理活性化合物的制备具有相当大的兴趣。哒嗪化合物还显示出抗饲料，杀虫，除草，杀软体动物，植物生长调节和其他农业化学活性。各种哒嗪类药物是选择性PDE-III抑制剂，具有正性肌力作用和血管舒张作用。这些药物可有效治疗各种心血管疾病，例如急性和慢性心力衰竭，心肌梗塞，心绞痛，心律不齐和高血压。哒嗪和酞嗪由于易于在各种环位置官能化而进一步引起我们的注意，这使它们成为将来设计和开发新型哒嗪和酞嗪药物的有吸引力的合成化合物。据报道，各种取代的哒嗪衍生物也显示出抗菌，抗真菌和抗病毒的特性。我们考虑了一些在分子框架中带有哒嗪的化合物。