当前位置: X-MOL 学术Diabetol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Serum 25-hydroxyvitamin D concentration in childhood and risk of islet autoimmunity and type 1 diabetes: the TRIGR nested case-control ancillary study.
Diabetologia ( IF 8.2 ) Pub Date : 2020-01-07 , DOI: 10.1007/s00125-019-05077-4
Maija E Miettinen 1 , Sari Niinistö 1 , Iris Erlund 1, 2 , David Cuthbertson 3 , Anita M Nucci 4 , Jarno Honkanen 5 , Outi Vaarala 5 , Heikki Hyöty 6, 7 , Jeffrey P Krischer 3 , Mikael Knip 8, 9, 10, 11 , Suvi M Virtanen 1, 12, 13, 14 ,
Affiliation  

AIMS/HYPOTHESIS Our aim was to study the association between serum 25-hydroxyvitamin D (25OHD) concentration and islet autoimmunity and type 1 diabetes in children with an increased genetic risk of type 1 diabetes. METHODS Serum samples for 25OHD measurements were obtained in the Trial to Reduce IDDM in the Genetically at Risk (TRIGR) ancillary study (Divia) from children in 15 countries. Case children (n = 244) were defined as having positivity for at least two out of four diabetes-associated autoantibodies measured at any one sample. For each case child, two control children were selected matched for country and date of birth (±1 year) (n = 488). Of the case children, 144 developed type 1 diabetes. Serum 25OHD was measured repeatedly in infancy and childhood and was compared according to age at the first seroconversion (at 6, 12 and 18 months prior to and at seroconversion) and calendar age (0, 6, 12 and 18 months). RESULTS In children with islet autoimmunity, mean serum 25OHD concentration was lower 18 months prior to the age of first seroconversion of the case children compared with the control children (57.7 vs 64.8 nmol/l, p = 0.007). In children with type 1 diabetes (n = 144), mean serum 25OHD concentration was lower 18 months prior to the age of the first seroconversion (58.0 vs 65.0 nmol/l, p = 0.018) and at the calendar age of 12 months (70.1 vs 75.9 nmol/l, p = 0.031) than in their control counterparts. Analyses were adjusted for month of sample collection, human leucocyte antigen genotype, maternal type 1 diabetes and sex. CONCLUSIONS/INTERPRETATION The results suggest that early postnatal vitamin D may confer protection against the development of type 1 diabetes. TRIAL REGISTRATION ClinicalTrials.gov NCT00179777.

中文翻译:

儿童期血清25-羟基维生素D浓度以及胰岛自身免疫性疾病和1型糖尿病的风险:TRIGR巢式病例对照辅助研究。

目的/假设我们的目的是研究患有1型糖尿病遗传风险增加的儿童血清25-羟维生素D(25OHD)浓度与胰岛自身免疫性和1型糖尿病之间的关系。方法在15个国家的儿童的遗传风险(TRIGR)辅助研究(Divia)中,从降低IDDM的试验中获得了用于25OHD测定的血清样品。病例儿童(n = 244)被定义为在任何一个样本中测得的四个与糖尿病相关的自身抗体中至少两个具有阳性。对于每例儿童,选择两个对照儿童以匹配其国家和出生日期(±1岁)(n = 488)。在本例儿童中,有144人患有1型糖尿病。在婴儿期和儿童期反复测量血清25OHD,并根据首次血清转换时的年龄(6岁时)进行比较。血清转化之前和血清转化之前的12和18个月)和日历年龄(0、6、12和18个月)。结果在患有胰岛自身免疫的儿童中,与对照儿童相比,该病例儿童在首次血清转化之前18个月的平均血清25OHD浓度较低(57.7 vs 64.8 nmol / l,p = 0.007)。在患有1型糖尿病的儿童(n = 144)中,在首次血清转化之前18个月(58.0 vs 65.0 nmol / l,p = 0.018)和在12个月的日历年龄(70.1)平均血清25OHD浓度较低。与75.9 nmol / l相比,p = 0.031)。调整分析以收集样品的月份,人类白细胞抗原基因型,母亲1型糖尿病和性别。结论/解释结果表明,出生后早期的维生素D可能赋予预防1型糖尿病发展的保护作用。试验注册ClinicalTrials.gov NCT00179777。
更新日期:2020-03-03
down
wechat
bug