Nerve guidance conduits (NGCs) can provide suitable microenvironment for nerve repair and promote the proliferation and migration of Schwann cells (SCs). Thus, we developed nerve guidance conduits (NGCs) with polypyrrole-coated polycaprolactone nanoyarns (PPy-PCL-NYs) as fillers in this study. PCL-NYs with the oriented structure were prepared with a double-needle electrospinning system and then PPy was coated on PCL-NYs via the in situ chemical polymerization. Subsequently, PCL nanofibers were collected around nanoyarns by the conventional electrospinning process as the outer layer to obtain PPy-PCL-NY nerve guidance conduits (PPy-PCLNY NGCs). PPy-PCL-NYs were analyzed by SEM, FTIR and XPS. Results showed that PPy was homogeneously and uniformly deposited on the surface of PCL-NY. Strain-stress curves and the Young’s modulus of PPy-PCL-NYs were investigated compared with those of non-coated PCL-NYs. Studies on biocompatibility with SCs indicated that PPy-PCL-NY NGCs were more conducive to the proliferation of SCs than PCL-NY NGCs. In summary, PPy-PCL-NY NGCs show the promising potential for nerve tissue engineering repair and regeneration.

神经引导导管（NGC）可以为神经修复提供合适的微环境，并促进雪旺细胞（SCs）的增殖和迁移。因此，在这项研究中，我们开发了以聚吡咯涂层的聚己内酯纳米纱线（PPy-PCL-NYs）为填充剂的神经引导导管（NGC）。用双针静电纺丝系统制备具有定向结构的PCL-NY，然后通过原位将PPy涂覆在PCL-NY上化学聚合。随后，通过常规电纺丝工艺将PCL纳米纤维收集在纳米纱线周围作为外层，从而获得PPy-PCL-NY神经引导导管（PPy-PCLNY NGC）。通过SEM，FTIR和XPS对PPy-PCL-NYs进行了分析。结果表明，PPy均匀而均匀地沉积在PCL-NY表面。研究了PPy-PCL-NYs与未涂覆的PCL-NYs的应变-应力曲线和杨氏模量。与SC的生物相容性研究表明，PPy-PCL-NY NGC比PCL-NY NGC更有利于SC的增殖。总之，PPy-PCL-NY NGCs在神经组织工程修复和再生方面显示出有希望的潜力。