The bacterial microflora that inhabits our body makes up the most complex microbial community called microbiota. The microbiota, which is evolutionarily fixed in the human body, has a significant effect on the maintenance of human health and functions. The study of the genotoxic potential of microflora, closely related to bacterial oncogenesis, remains incomplete. When the imbalance of healthy microflora is violated under the influence of various factors, including mutagens and environmental carcinogens, the composition of the microbiota is transformed into an aggressive form. It has been suggested that such changes lead to functional metabolism shifts in bacterial communities, which leads to a progression of malignant growth in these parts of the host organism. Bacteria are able to influence pathogenic processes occurring during the course of the disease, producing effectors of DNA damage in the cells of the host organism or modifying the body’s ability to metabolize mutagens and carcinogens. We present in this work evidence and hypotheses about the ability of pathogenic and commensal bacteria with genotoxic potential to lead to the development of oncological diseases. This paper examines individual organs (intestines, stomach, respiratory tract, gallbladder and mammary gland), whose carcinogenesis is influenced by bacteria that can damage the DNA of the host cells.

中文翻译：

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人类细菌菌群组成：与其在各种器官中的变化相关的遗传毒性和致癌作用

居住在我们体内的细菌菌群构成了最复杂的微生物群落，称为微生物群。微生物群在人体内进化固定，对维持人体健康和功能具有显着影响。与细菌肿瘤发生密切相关的微生物群落的遗传毒性潜力的研究仍然不完整。当健康微生物群的失衡在诱变剂和环境致癌物等各种因素的影响下被破坏时，微生物群的组成就会转变为具有侵略性的形式。有人提出，这种变化会导致细菌群落的功能代谢发生变化，从而导致宿主生物体这些部分的恶性生长。细菌能够影响疾病过程中发生的致病过程，在宿主生物的细胞中产生 DNA 损伤效应物或改变身体代谢诱变剂和致癌物的能力。我们在这项工作中提出了关于具有遗传毒性潜力的致病菌和共生细菌导致肿瘤疾病发展的能力的证据和假设。本文研究了单个器官（肠、胃、呼吸道、胆囊和乳腺），它们的致癌作用受到细菌的影响，细菌会破坏宿主细胞的 DNA。我们在这项工作中提出了关于具有遗传毒性潜力的致病菌和共生细菌导致肿瘤疾病发展的能力的证据和假设。本文研究了单个器官（肠、胃、呼吸道、胆囊和乳腺），它们的致癌作用受到细菌的影响，细菌会破坏宿主细胞的 DNA。我们在这项工作中提出了关于具有遗传毒性潜力的致病菌和共生细菌导致肿瘤疾病发展的能力的证据和假设。本文研究了单个器官（肠、胃、呼吸道、胆囊和乳腺），它们的致癌作用受到细菌的影响，细菌会破坏宿主细胞的 DNA。