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Molecular and cellular mechanisms of the organogenesis and development of the mammalian carotid body.
Developmental Dynamics ( IF 2.5 ) Pub Date : 2019-12-30 , DOI: 10.1002/dvdy.144 Yoko Kameda 1
Developmental Dynamics ( IF 2.5 ) Pub Date : 2019-12-30 , DOI: 10.1002/dvdy.144 Yoko Kameda 1
Affiliation
Despite significant advancements in understanding physiological properties of the carotid body, little attention has been paid to its organogenesis. This review addresses the molecular and cellular mechanisms underlying organogenesis of the carotid body in mammals. The carotid body consists of two types of cells, that is, glomus cells and sustentacular cells, that are derived from different origins. Glomus cells are derivatives of neural crest cells which form sympathetic ganglia. Sustentacular cells are derivatives of mesenchymal neural crest cells which colonize the third pharyngeal arch and form the wall of the third arch artery. Gene-targeting studies indicate that three elements are required for carotid body organogenesis: the carotid sinus nerve (CSN), third arch artery, and superior cervical sympathetic ganglion (SCG). The CSN sends sensory fibers and Schwann cells to the wall of the third arch artery. The third arch artery provides mesenchymal cells, which give rise to sustentacular cells. The nerve process from the SCG sends glomus cell progenitors into the carotid body primordium. The presence of stem cells in the adult carotid body was recently highlighted. The origin of stem cells, however, remains controversial. Based on embryonic development of the carotid body, this review proposes the origin of stem cells.
中文翻译:
哺乳动物颈动脉体器官发生和发育的分子和细胞机制。
尽管在理解颈动脉体的生理特性方面取得了重大进展,但对其器官发生的关注很少。这篇综述讨论了哺乳动物颈动脉体器官发生的分子和细胞机制。颈动脉体由两种不同来源的细胞组成,即血管球细胞和支持细胞。球细胞是形成交感神经节的神经嵴细胞的衍生物。支持细胞是间充质神经嵴细胞的衍生物,其定植于第三咽弓并形成第三弓动脉壁。基因靶向研究表明颈动脉体器官发生需要三个要素:颈动脉窦神经 (CSN)、第三弓动脉和颈上交感神经节 (SCG)。CSN 将感觉纤维和雪旺氏细胞发送到第三弓动脉壁。第三弓动脉提供间充质细胞,产生支持细胞。来自 SCG 的神经过程将球细胞祖细胞发送到颈动脉体原基。最近强调了成人颈动脉体中干细胞的存在。然而,干细胞的起源仍然存在争议。本综述基于颈动脉体的胚胎发育,提出了干细胞的起源。然而,仍然存在争议。本综述基于颈动脉体的胚胎发育,提出了干细胞的起源。然而,仍然存在争议。本综述基于颈动脉体的胚胎发育,提出了干细胞的起源。
更新日期:2019-12-30
中文翻译:
哺乳动物颈动脉体器官发生和发育的分子和细胞机制。
尽管在理解颈动脉体的生理特性方面取得了重大进展,但对其器官发生的关注很少。这篇综述讨论了哺乳动物颈动脉体器官发生的分子和细胞机制。颈动脉体由两种不同来源的细胞组成,即血管球细胞和支持细胞。球细胞是形成交感神经节的神经嵴细胞的衍生物。支持细胞是间充质神经嵴细胞的衍生物,其定植于第三咽弓并形成第三弓动脉壁。基因靶向研究表明颈动脉体器官发生需要三个要素:颈动脉窦神经 (CSN)、第三弓动脉和颈上交感神经节 (SCG)。CSN 将感觉纤维和雪旺氏细胞发送到第三弓动脉壁。第三弓动脉提供间充质细胞,产生支持细胞。来自 SCG 的神经过程将球细胞祖细胞发送到颈动脉体原基。最近强调了成人颈动脉体中干细胞的存在。然而,干细胞的起源仍然存在争议。本综述基于颈动脉体的胚胎发育,提出了干细胞的起源。然而,仍然存在争议。本综述基于颈动脉体的胚胎发育,提出了干细胞的起源。然而,仍然存在争议。本综述基于颈动脉体的胚胎发育,提出了干细胞的起源。