Due to the development of Marine aquaculture, infections caused by Vibrio vulnificus are common all over the world. Symptoms of V. vulnificus infection vary from gastrointestinal illness to septicemia. After infection with V. vulnificus, some patients showed gastrointestinal symptoms, including vomiting, fever, diarrhea, and so on. Others appeared wound infection at the site of contact with bacteria, and even developed sepsis. Once it develops into sepsis, the prognosis of patients is very poor. However, its underlying pathogenic mechanism remains largely undetermined. Growing evidence shows that it can induce primary septicemia mainly via essential virulence factors and regulators. Therefore, it is important to identify the factors that play roles in sepsis. In this review, we systematically expounded the role of V. vulnificus virulence factors and regulators in its infection-induced sepsis in order to provide useful information for the treatment and prevention of V. vulnificus.

由于海洋水产养殖的发展，由创伤弧菌引起的感染在世界各地很普遍。Vulnificus感染的症状从胃肠道疾病到败血病不等。创伤弧菌感染后，一些病人表现出胃肠道症状，包括呕吐，发烧，腹泻等。其他人在与细菌接触的部位出现伤口感染，甚至出现败血症。一旦发展成败血症，患者的预后就很差。但是，其潜在的致病机制仍未确定。越来越多的证据表明，它可以主要通过必需的毒力因子和调节剂诱导原发性败血病。因此，确定在败血症中起作用的因素很重要。在这篇综述中，我们系统地阐述了V. vulnificus毒力因子和调节剂在其感染引起的败血症中的作用，以便为V. vulnificus的治疗和预防提供有用的信息。