In the body, millions of cells die and proliferate each day to maintain normal function and cooperation of all tissues, organs, and systems. Thus, programmed cell death, or apoptosis, is critical to sustain growth, development, and body health. The vital role of B-cell leukemia/lymphoma-2 (BCL-2) family proteins in apoptosis has been identified. The BCL-2 family includes both pro- and antiapoptotic proteins, which are structurally and functionally related, containing up to four BCL-2 homology (BH) motifs (BH1-4). There are also some nutritional factors that regulate apoptosis via the BCL-2 family proteins. In this review, the BCL-2 family proteins and their apoptosis-inducing mechanism have been discussed, along with the nutrient factors that regulate apoptosis through the BCL-2 family proteins.

在体内，每天有数百万个细胞死亡并增殖，以维持正常功能以及所有组织，器官和系统的协作。因此，程序性细胞死亡或细胞凋亡对于维持生长，发育和身体健康至关重要。已确定B细胞白血病/淋巴瘤2（BCL-2）家族蛋白在细胞凋亡中的重要作用。BCL-2家族既包含促凋亡蛋白，也包括抗凋亡蛋白，它们在结构和功能上均相关，最多包含四个BCL-2同源性（BH）模体（BH1-4）。也有一些营养因子通过BCL-2家族蛋白调节细胞凋亡。在这篇综述中，已经讨论了BCL-2家族蛋白及其诱导凋亡的机制，以及通过BCL-2家族蛋白调节细胞凋亡的营养因子。