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Differences in Cell Proliferation and Craniofacial Phenotype of Closely Related Species in the Pupfish Genus Cyprinodon
Journal of Heredity ( IF 3.1 ) Pub Date : 2019-12-07 , DOI: 10.1093/jhered/esz074 Ezra Lencer 1, 2 , Amy R McCune 1
Journal of Heredity ( IF 3.1 ) Pub Date : 2019-12-07 , DOI: 10.1093/jhered/esz074 Ezra Lencer 1, 2 , Amy R McCune 1
Affiliation
Understanding the genetic basis for phenotypic differences is fundamental to the study of macroevolutionary patterns of biological diversity. While technological advances in DNA sequencing have made researching genetic variation in wild taxa routine, fully understanding how these variants affect phenotype requires taking the next step to investigate how genetic changes alter cell and tissue interactions that ultimately produce phenotypes. In this paper, we investigate a role for cell proliferation as a developmental source of craniofacial diversity in a radiation of three species of Cyprinodon from San Salvador Island, Bahamas. Patterns of cell proliferation in the heads of hatching-age fish differ among species of Cyprinodon, and correlate with differences in allometric growth rate among the jaws of three distinct species. Regional patterns of cell proliferation in the head are complex, resulting in an unintuitive result in which lower levels of cell proliferation in the posterior head region are associated with the development of relatively larger jaws in one species. We combine these data with previously published morphological and genomic data to show how studying the mechanisms generating phenotype at the cellular and tissue levels of biological organization can help mechanistically link genomic studies with classic morphological studies.
中文翻译:
鲽鱼属近缘种细胞增殖和颅面表型的差异
了解表型差异的遗传基础是研究生物多样性宏观进化模式的基础。虽然 DNA 测序的技术进步使研究野生分类群的遗传变异成为常规,但要充分了解这些变异如何影响表型,还需要采取下一步研究遗传变化如何改变最终产生表型的细胞和组织相互作用。在本文中,我们研究了细胞增殖作为颅面多样性发育来源在来自巴哈马圣萨尔瓦多岛的三种鲤鱼的辐射中的作用。不同种类的鲤鱼,孵化期鱼头部的细胞增殖模式不同,并且与三种不同物种的颌部异速生长速率的差异相关。头部细胞增殖的区域模式是复杂的,导致一个不直观的结果,即后头部区域的细胞增殖水平较低与一个物种的相对较大的颌部的发育有关。我们将这些数据与先前发表的形态学和基因组数据相结合,以展示研究在生物组织的细胞和组织水平上产生表型的机制如何帮助将基因组研究与经典形态学研究机械地联系起来。
更新日期:2019-12-07
中文翻译:
鲽鱼属近缘种细胞增殖和颅面表型的差异
了解表型差异的遗传基础是研究生物多样性宏观进化模式的基础。虽然 DNA 测序的技术进步使研究野生分类群的遗传变异成为常规,但要充分了解这些变异如何影响表型,还需要采取下一步研究遗传变化如何改变最终产生表型的细胞和组织相互作用。在本文中,我们研究了细胞增殖作为颅面多样性发育来源在来自巴哈马圣萨尔瓦多岛的三种鲤鱼的辐射中的作用。不同种类的鲤鱼,孵化期鱼头部的细胞增殖模式不同,并且与三种不同物种的颌部异速生长速率的差异相关。头部细胞增殖的区域模式是复杂的,导致一个不直观的结果,即后头部区域的细胞增殖水平较低与一个物种的相对较大的颌部的发育有关。我们将这些数据与先前发表的形态学和基因组数据相结合,以展示研究在生物组织的细胞和组织水平上产生表型的机制如何帮助将基因组研究与经典形态学研究机械地联系起来。