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Investigating the effect of freezing temperature and cross-linking on modulating drug release from chitosan scaffolds
Chemical Papers ( IF 2.2 ) Pub Date : 2019-12-09 , DOI: 10.1007/s11696-019-01024-0
Eshwari Dathathri , Goutam Thakur , K. B. Koteshwara , N. V. Anil Kumar , Fiona Concy Rodrigues

The aim of this study was to investigate the effect of altering design variables like cross-linking and freezing temperature (at a time) on morphology of freeze-dried chitosan scaffolds and modulation of release of Diclofenac sodium (model drug). Freeze-dried chitosan scaffolds produced at − 80 °C, cross-linked with genipin, showed swelling of 163.52 ± 9.95% with sustained drug release of 26.37 ± 10.47% over 24 h (P < 0.05). In comparison, uncross-linked scaffolds produced at − 80 °C showed higher swelling of 173.58 ± 8.23% and drug release of 28.67 ± 2.40% (P < 0.05). Uncross-linked scaffolds produced using freezing temperature of − 20 °C also showed higher swelling of 228.77 ± 9.84% and release of 30.58 ± 3.25% (P < 0.05). Release kinetics followed Higuchi model with Fickian diffusion, thereby indicating a swelling-dependent release. Altering the design parameters also showed significant changes in pore size and porosity, thereby supporting the swelling and drug delivery behavior from scaffolds.

中文翻译:

研究冷冻温度和交联对调节壳聚糖支架药物释放的影响

这项研究的目的是研究改变设计变量(如一次交联和冷冻温度)对冷冻干燥的壳聚糖支架的形态和双氯芬酸钠(模型药物)释放的调节的影响。冷冻干燥的壳聚糖支架在-80°C下与Genipin交联,在24小时内溶胀为163.52±9.95%,药物的持续释放率为26.37±10.47%(P  <0.05)。相比之下,在-80°C下生产的未交联支架显示出更高的溶胀率173.58±8.23%,药物释放率更高,为28.67±2.40%(P  <0.05)。在− 20°C的冷冻温度下生产的未交联支架也显示出更高的溶胀228.77±9.84%和释放30.58±3.25%(P <0.05)。释放动力学遵循具有Fickian扩散的Higuchi模型,从而表明了溶胀依赖性释放。改变设计参数还显示出孔径和孔隙率的显着变化,从而支持了支架的溶胀和药物递送行为。
更新日期:2019-12-09
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