In severe periodontitis, bacteria-induced inflammation causes destruction of the tooth supporting structure, which if left untreated will lead to tooth loss. Current conventional strategies aiming to eliminate pathogenic biofilms and control infection and inflammation, either nonsurgically or surgically, cannot regenerate functional periodontal tissues.^1,2 Even using various regenerative procedures, such as bone grafting, guided tissue/bone regeneration, use of recombinant growth factors, and enamel matrix derivative applications,^3,4 success in regenerating periodontium is limited and unpredictable. Therefore, development of novel tissue engineering strategies to completely regenerate the lost alveolar bone, periodontal ligament (PDL), and cementum is urgently required.

中文翻译：

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EphrinB2调节比格犬牙周膜干细胞的成骨分化和牙槽骨缺损的再生

在严重的牙周炎中，细菌引起的炎症会导致牙齿支撑结构破坏，如果不及时治疗，将导致牙齿脱落。旨在消除病原性生物膜并控制感染和炎症的当前常规策略，无论是通过非手术方式还是通过手术方式，都无法再生功能性牙周组织。^1,2即使使用各种再生程序，例如植骨，引导组织/骨再生，使用重组生长因子和牙釉质基质衍生物应用，^3,4在再生牙周膜方面的成功也是有限且不可预测的。因此，迫切需要开发新颖的组织工程策略以完全再生丢失的牙槽骨，牙周膜（PDL）和牙骨质。