Objective:

Sleep–wake disturbances, such as excessive daytime somnolence (EDS), are nonmotor symptoms of Parkinson's disease (PD) and significantly affect the quality of life. This study aimed to examine the relationship between EDS and motor and nonmotor symptoms of PD.

Methods:

Eighty-two patients with idiopathic mild PD were followed up twice a year for 2 years and assessed on sleep, mood, anxiety, cognition, function, and disease severity. Data were analyzed retrospectively, comparing motor and nonmotor outcomes between those with EDS and those without.

Results:

At baseline, 27.9% had EDS and were similar in demographic and clinical characteristics to those without; 10% had persistent EDS during the first year of follow-up. Excessive daytime somnolence had a significant main effect on mood and anxiety as shown by consistently higher scores on the Geriatric Depression Scale (P = .022) and Hospital Anxiety and Depression Scale-Anxiety subscale scores (P = .011) throughout duration of follow-up. The group with persistent EDS showed greater rate of worsening Frontal Assessment Battery scores by the end of first-year follow-up (P = .025) and greater rate of worsening Apathy Scale scores by the end of 2-year follow-up (P = .002). No significant effects of EDS on motor symptoms and disease severity were found.

Conclusions:

In a Southeast Asian cohort of patients with PD, EDS had a negative longitudinal impact on mood, anxiety, apathy, and cognitive function but no impact on motor symptoms and disease severity. Excessive daytime somnolence is thus a potential therapeutic target to improve nonmotor outcomes.

中文翻译：

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东南亚人群白天过度嗜睡对帕金森氏病运动和非运动症状的纵向影响

目的：

睡眠-觉醒障碍，例如白天过度嗜睡（EDS），是帕金森氏病（PD）的非运动性症状，并严重影响生活质量。这项研究旨在检查EDS与PD的运动和非运动症状之间的关系。

方法：

每年对82例特发性轻度PD患者进行两次随访，为期2年，并就睡眠，情绪，焦虑，认知，功能和疾病严重程度进行评估。回顾性分析数据，比较有EDS者和无EDS者的运动和非运动结果。

结果：

基线时，有27.9％的人患有EDS，人口统计学和临床​​特征与没有EDS的相似。在随访的第一年中，有10％的患者持续存在EDS。白天的过度嗜睡对情绪和焦虑有显着的主要影响，在随访期间，老年抑郁量表（P = .022）和医院焦虑和抑郁量表-焦虑子量表的得分（P = .011）始终较高。向上。持续EDS组在第一年随访结束时表现出的额叶评估电池评分恶化率更高（P = .025），在两年随访结束时表现出的无意识量表评分恶化率更高（P= .002）。没有发现EDS对运动症状和疾病严重程度有明显影响。

结论：

在东南亚PD患者队列中，EDS对情绪，焦虑，冷漠和认知功能具有负面的纵向影响，但对运动症状和疾病的严重程度没有影响。因此，白天过多的嗜睡症是改善非运动状态的潜在治疗目标。