Some new 2-[5-(aryl)-[1,3,4]oxadiazole-2-ylsulfanyl]alkanoic acids were synthesized and studied for their antibacterial activity. These compounds were prepared from aromatic carboxylic acid hydrazides. Aromatic carboxylic acid hydrazides 1 on refluxing with carbon disulfide and methanolic potassium hydroxide and then on subsequent acidification with hydrochloric acid furnish 5-aryl-1,3,4-oxadiazole-2-thiones 2. 2-Chloro alkanoic acids react with 2 in alkaline media and on acidification yield the title compounds 3. These compounds were characterised by CHN analyses, IR, mass and ¹H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and their minimum inhibitory concentration (MIC) were determined.

中文翻译：

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某些2- [5-（芳基）-[1,3,4]恶二唑-2-基硫烷基]链烷酸的合成及抗菌研究

合成了一些新的2- [5-（芳基）-[1,3,4]恶二唑-2-基硫烷基]链烷酸，并研究了它们的抗菌活性。这些化合物由芳族羧酸酰肼制备。芳族羧酸酰肼1在与二硫化碳和甲醇氢氧化钾回流下，然后在随后用盐酸酸化时，得到5-芳基-1,3,4-恶二唑-2-硫酮2。2-氯链烷酸在碱性介质中与2反应，酸化后得到标题化合物3。这些化合物通过CHN分析，IR，质量和¹ H NMR光谱数据表征。所有化合物均经过体外评估确定了对两种革兰氏阴性菌株（大肠杆菌和铜绿假单胞菌）和两种革兰氏阳性菌株（枯草芽孢杆菌和金黄色葡萄球菌）的抗菌活性及其最低抑菌浓度（MIC）。