Owing to the importance of multifunctional theranostics as promising systems to overcome key problems of conventional cancer therapy, in this study a multifunctional metal–organic framework-based (MOF) theranostic system was prepared and applied as intelligent theranostic systems in cancer. Iron-based MOF, MIL-88B, in a multi-faceted shape was initially prepared. Curcumin (Cur) was then loaded into the pores of MIL and folic acid–chitosan conjugate (FC) was finally coated on the surface of the carrier to accomplish cancer-specific targeting properties. MTT assay revealed perfect cytocompatibility of the system and selective toxicity against cancerous cells. In vivo MRI images showed high tumour uptake for MIL-Cur@FC and high T₁–T₂ contrast effect. The growth inhibiting efficiencies of MIL-Cur@FC on M109 tumour bearing Balb/C mice without reducing their body weight showed maximum tumour eradication with no significant toxicities. Due to the outstanding features of the system achieved from in vitro and in vivo studies, we believe that this study will provide a novel approach for developing targeted theranostic agents in cancer diagnosis and treatment.

由于多功能治疗诊断系统作为克服传统癌症治疗关键问题的有前途的系统的重要性，本研究制备了一种多功能金属有机框架（MOF）治疗诊断系统，并将其用作癌症中的智能治疗诊断系统。最初制备了多面形状的铁基 MOF，MIL-88B。然后将姜黄素 (Cur) 装入 MIL 的孔中，最后将叶酸-壳聚糖偶联物 (FC) 涂覆在载体表面以实现癌症特异性靶向特性。MTT 测定揭示了该系统的完美细胞相容性和对癌细胞的选择性毒性。体内MRI 图像显示 MIL-Cur@FC 的高肿瘤摄取和高 T ₁ -T ₂对比效果。MIL-Cur@FC 对 M109 荷瘤 Balb/C 小鼠的生长抑制效率显示出最大程度的肿瘤根除，无显着毒性。由于该系统在体外和体内研究中取得的突出特点，我们相信这项研究将为开发用于癌症诊断和治疗的靶向治疗诊断剂提供一种新方法。