Telomere attachment to the nuclear envelope (NE) is a prerequisite for chromosome movement during meiotic prophase I and is required for pairing, synapsis, and recombination of homologous chromosomes. Over the past decade, components of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which functions as a bridge to link the chromosomes and the cytoskeleton, have been reported [1]. Two components of the LINC complex, Sad1 and UNC84 domain-containing 1 (SUN1) and Klarsicht/ANC-1/Syne/homology 5 (KASH5), were first reported to cross the inner and outer nuclear membranes, respectively. KASH5 interacts with the microtubule-associated dynein–dynactin complex [2, 3] and SUN1...

中文翻译：

---

保护避难所复合物是减数分裂前期I期间端粒束缚于核膜的关键

端粒附着在核膜上（NE）是减数分裂前期I期间染色体运动的先决条件，并且是同源染色体的配对，突触和重组所必需的。在过去的十年中，已经报道了核骨架和细胞骨架（LINC）复合物的连接子的成分，该复合物起着连接染色体和细胞骨架的桥梁的作用[1]。首次报道了LINC复合物的两个成分，即Sad1和UNC84域含1（SUN1）和Klarsicht / ANC-1 / Syne / homology 5（KASH5），分别穿过内核膜和外核膜。KASH5与微管相关的动力蛋白-动力蛋白复合物[2，3]和SUN1相互作用。