As the HIV epidemic has evolved, so too has the role of the clinical pharmacist (CP) in the management of people living with HIV (PLWH). The modern antiretroviral therapy (ART) era has resulted in PLWH living normal life spans with resulting increased comorbidities. CPs have long been a part of the multidisciplinary management of ART. However, with the changing demographics of PLWH and health-care system dynamics, CPs have had the opportunity to expand their role. This includes involvement in managing increasing comorbidities with expanding and more complicated medication regimens, drug interaction monitoring, and optimizing transitions of care, all while recognizing and addressing barriers to successful HIV and hepatitis C virus (HCV) treatment. In addition, with the expansion of HIV prevention and pre-exposure prophylaxis (PrEP) services, CPs have the opportunity to be involved in HIV prevention. This study summarizes the literature evaluating the impact of CPs in the management of PLWH in the era of modern ART. We conducted a literature search to identify studies that assessed the CP role in HIV clinical practice since 2006. The identified studies were grouped into two categories. The first was HIV related outcomes, including interventions on regimen selection, adherence, regimen optimization, and management of treatment failure. The second group of studies pertained to aging and vulnerable populations, including management of comorbidities, transitions of care, medication-assisted treatment, hepatitis C, and HIV screening and PrEP. We concluded that the evidence supports the expanding role of CPs to positively impact a variety of aspects related to the care of PLWH.

中文翻译：

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在现代抗逆转录病毒时代，临床药剂师在HIV感染者管理中的作用。

随着艾滋病流行的发展，临床药剂师（CP）在管理艾滋病病毒感染者（PLWH）中的作用也不断提高。现代抗逆转录病毒疗法（ART）时代已使PLWH维持正常的寿命，并导致合并症增加。CP长期以来一直是ART跨学科管理的一部分。但是，随着艾滋病毒/艾滋病感染者的人口统计变化和卫生保健系统的动态变化，CP有了机会扩大其作用。这包括通过识别和解决成功治疗HIV和丙型肝炎的障碍，参与通过扩大和更复杂的药物治疗方案来管理合并症的不断发展，药物相互作用的监测以及优化护理的过渡。此外，随着HIV预防和暴露前预防（PrEP）服务的扩展，社区成员有机会参与艾滋病毒的预防。这项研究总结了评估CP在现代ART时代对PLWH管理中的影响的文献。我们进行了文献检索，以鉴定自2006年以来评估CP在HIV临床实践中作用的研究。已鉴定的研究分为两类。首先是与HIV相关的结果，包括对方案选择，依从性，方案优化和治疗失败的干预。第二组研究涉及老龄化和弱势群体，包括合并症的管理，护理的过渡，药物辅助治疗，丙型肝炎，艾滋病毒筛查和PrEP。我们得出的结论是，证据支持了CP的扩大作用，从而对与PLWH护理相关的各个方面产生了积极影响。