Obesity reaches an epidemic level worldwide, and this condition is associated with chronic low-grade inflammation and secondary comorbidities, largely driven by global changes in lifestyle and diet. Various dietary approaches are proposed for the obesity treatment and its associated metabolic disorders. Good taste, antioxidant functions, and vitamins have been attributed to virgin coconut oil (VCO). However, VCO contains a large amount of saturated fatty acids, and the consumption of this fat is associated with a number of secondary diseases. We evaluate the effects of VCO supplementation on biochemical, inflammatory, and oxidative stress parameters in rats fed with high-fat diet (HFD). After feeding with HFD for 12 weeks, the animals were supplemented with VCO for 30 days. HFD+VCO group increased in diet intake, weight gain, low-density lipoprotein cholesterol level, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. These findings were accompanied by increased in hepatic lipid profile and fat deposition in the liver. Adipocyte hypertrophy was observed in the HFD+VCO group, which was associated with elevated expression of tumor necrosis factor alpha (TNF-α) in adipose tissue. These results revealed that VCO associated with HFD induced important metabolic alterations, adipose inflammation, and hepatic lipid accumulation in rats.

中文翻译：

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初榨椰子油与高脂饮食相关，可引起代谢功能障碍，脂肪炎症和肝脂质蓄积。

肥胖症在世界范围内达到流行病的水平，并且这种病状与慢性低度炎症和继发合并症相关，很大程度上由生活方式和饮食的全球变化所驱动。提出了多种饮食方法用于肥胖症治疗及其相关的代谢紊乱。良好的口感，抗氧化功能和维生素归因于原始椰子油（VCO）。但是，VCO含有大量的饱和脂肪酸，这种脂肪的消耗与许多继发性疾病有关。我们评估补充高脂饮食（HFD）的大鼠中VCO对生化，炎症和氧化应激参数的影响。用HFD喂养12周后，给动物补充VCO 30天。HFD + VCO组的饮食摄入，体重增加，低密度脂蛋白胆固醇水平以及天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的水平。这些发现伴随着肝脏脂质分布和肝脏脂肪沉积的增加。在HFD + VCO组中观察到脂肪细胞肥大，这与肿瘤坏死因子α（TNF-脂肪组织中的α）。这些结果表明，与HFD相关的VCO在大鼠中引起重要的代谢改变，脂肪炎症和肝脂质蓄积。