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Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh
Clinical Phytoscience Pub Date : 2019-12-23 , DOI: 10.1186/s40816-019-0138-7
Musri Musman , Mauli Zakia , Ratu Fazlia Inda Rahmayani , Erlidawati Erlidawati , Safrida Safrida

Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence. The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.

中文翻译:

抗2型糖尿病对马六甲(Phyllanthus emblica L.)果肉酚提取物的药物打击

社区中的民族植物学知识已经塑造了当地人利用植物治疗疾病的智慧,例如使用马六甲(Phyllanthus emblica)的肉来治疗2型糖尿病。这项研究提供了证据,表明马六甲果肉的酚类提取物可以降低糖尿病诱导大鼠的血糖水平。对Wistar菌株Rattus norvegicus的葡萄糖诱导的大鼠给予甘蓝假单胞菌的酚提取物治疗14天,其中将二甲双胍用作阳性对照。通过与血糖水平相关的双向ANOVA软件和与组织病理学研究相关的SAS软件对生成的数据进行了95%的置信度分析。浓度为100和200 mg / kg体重的酚类提取物可以降低糖尿病大鼠的血糖水平。事后Dunnet测试表明,以100 mg / kg体重的浓度向大鼠给药提取物证明,与以200 mg / kg的浓度给予提取物相比,血糖水平显着降低,并且修复了受损细胞公斤体重的身体。证据表明,马六甲果肉的酚类提取物可以用作抗2型糖尿病,而不会损害其他器官。
更新日期:2019-12-23
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