当前位置: X-MOL 学术Scand. J. Clin. Lab. Invest. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The thromboelastography G parameter as a potential biomarker of acute coronary syndrome.
Scandinavian Journal of Clinical and Laboratory Investigation ( IF 2.1 ) Pub Date : 2020-01-03 , DOI: 10.1080/00365513.2019.1709986
Qingfen Zhou 1 , Minjing Mao 2 , Jun Meng 2 , Kaifeng Shi 2 , Jing Lin 3 , Qiuya Lu 2
Affiliation  

The most prominent event that defines acute coronary syndrome (ACS) is the formation of an intra-arterial thrombus, usually resulting from activation of platelet and fibrinogen at the ruptured plaque. Usually, conventional coagulation tests (CCTs) are used to estimate the hemostatic properties of patients. However, CCTs have significant limitations because they each assess individual aspects of the coagulation cascade, which is a complex multifaceted process. And CCTs are performed with platelet-poor plasma, while the contribution of platelets to clot formation is not measured. In contrast, thromboelastography (TEG) is a test for global hemostasis with whole blood, from the beginning of coagulation through clot formation to the ending with fibrinolysis. The aim of this study was to investigate whether TEG parameters could be surrogate biomarkers of thrombus formation process and diagnosis of ACS. Receiver operating characteristic(ROC)curve was used to evaluate the diagnosis performance of each index. Logistic regression analysis was utilized to define the independent risk factors of ACS. The results showed that the shear elastic modulus parameter (G) was an independent diagnostic indicator for ACS (odds ratio [OR], 2.600; 95% confidence interval [CI], 2.035–3.322). The area under ROC curve of G was 0.866. The optimal cut-off value for the diagnosis of ACS was 10.55 dyne/cm2, while the sensitivity was 66.2% and the specificity was 92.4%. In conclusion, G could be used as an optimal indicator of activation of platelet and fibrinogen, which is eligible to be a useful biomarker for early diagnosis of ACS.



中文翻译:

血栓弹力图G参数可作为急性冠状动脉综合征的潜在生物标记。

定义急性冠脉综合征(ACS)的最突出事件是动脉内血栓的形成,通常是由于斑块破裂时血小板和纤维蛋白原的活化所致。通常,使用常规凝血试验(CCT)评估患者的止血特性。但是,CCT有很大的局限性,因为它们各自评估凝血级联反应的各个方面,这是一个复杂的多方面过程。CCTs是在血小板贫血的血浆中进行的,而血小板对血凝块形成的贡献却无法测量。相比之下,血栓弹力描记术(TEG)是一种从全血止血的试验,从凝结开始到形成血块再到纤维蛋白溶解结束为止。这项研究的目的是调查TEG参数是否可以作为血栓形成过程和ACS诊断的替代生物标志物。采用受试者工作特征(ROC)曲线评价各指标的诊断性能。利用逻辑回归分析确定ACS的独立危险因素。结果表明,剪切弹性模量参数(G)是ACS的独立诊断指标(比值[OR]为2.600; 95%置信区间[CI]为2.035-3.322)。G的ROC曲线下面积为0.866。诊断ACS的最佳临界值为10.55达因/厘米 利用逻辑回归分析确定ACS的独立危险因素。结果表明,剪切弹性模量参数(G)是ACS的独立诊断指标(比值[OR]为2.600; 95%置信区间[CI]为2.035-3.322)。G的ROC曲线下面积为0.866。诊断ACS的最佳临界值为10.55达因/厘米 利用逻辑回归分析确定ACS的独立危险因素。结果表明,剪切弹性模量参数(G)是ACS的独立诊断指标(比值[OR]为2.600; 95%置信区间[CI]为2.035-3.322)。G的ROC曲线下面积为0.866。诊断ACS的最佳临界值为10.55达因/厘米与图2相比,灵敏度为66.2%,特异性为92.4%。总之,G可以用作血小板和纤维蛋白原激活的最佳指标,可以作为ACS早期诊断的有用生物标记。

更新日期:2020-04-18
down
wechat
bug