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Antibacterial activity of the venom of the Ponerine ant Pachycondyla striata (Formicidae: Ponerinae)
International Journal of Tropical Insect Science ( IF 1.2 ) Pub Date : 2020-01-06 , DOI: 10.1007/s42690-019-00090-x
Pollyanna Pereira Santos , Gracielle Rodrigues Pereira , Edvaldo Barros , Humberto Josué Oliveira Ramos , Leandro Licursi Oliveira , José Eduardo Serrão

Animal venom peptides have been reported as potential antimicrobial molecules for the development of novel antibiotics against resistant bacteria. Recent studies indicate that ant venoms is an important source of novel antimicrobial peptides. In the present study, the antimicrobial activity of the venom of the predatory ant Pachycondyla striata Smith, 1858, was evaluated against some pathogenic bacteria of medical importance. Growth inhibition tests revealed that the venom has broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria. Mass spectrometry analysis of the fractions with antimicrobial activity allowed the identification of venom allergen and venom allergen 5 as well as a peptide of unknown sequence. These three compounds exhibited antibacterial activity against the tested human pathogens.

中文翻译:

Perine ant Pachycondyla striata (Formicidae: Ponerinae) 毒液的抗菌活性

据报道,动物毒液肽是潜在的抗微生物分子,可用于开发针对耐药细菌的新型抗生素。最近的研究表明,蚂蚁毒液是新型抗菌肽的重要来源。在本研究中,1858 年捕食性蚂蚁 Pachycondyla striata Smith 的毒液对某些具有医学重要性的病原菌的抗菌活性进行了评估。生长抑制试验表明,该毒液对革兰氏阳性菌和革兰氏阴性菌具有广谱抗菌活性。对具有抗微生物活性的馏分进行质谱分析可以鉴定毒液过敏原和毒液过敏原 5 以及未知序列的肽。这三种化合物对测试的人类病原体表现出抗菌活性。
更新日期:2020-01-06
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