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Sexual dimorphism in cognitive disorders in a murine model of neuropathic pain
Behavioral and Brain Functions ( IF 5.1 ) Pub Date : 2020-01-04 , DOI: 10.1186/s12993-019-0164-0
Soonmi Won 1 , Keebum Park 1, 2 , Hyoungsub Lim 1 , Sung Joong Lee 1, 2
Affiliation  

A sex-difference in susceptibility to chronic pain is well-known. Although recent studies have begun to reveal the sex-dependent mechanisms of nerve injury-induced pain sensitization, sex differences in the affective and cognitive brain dysfunctions associated with chronic pain have not been investigated. Therefore, we tested whether chronic pain leads to affective and cognitive disorders in a mouse neuropathic pain model and whether those disorders are sexually dimorphic. Chronic neuropathic pain was induced in male and female mice by L5 spinal nerve transection (SNT) injury. Pain sensitivity was measured with the von Frey test. Affective behaviors such as depression and anxiety were assessed by the forced swim, tail suspension, and open field tests. Cognitive brain function was assessed with the Morris water maze and the novel object location and novel object recognition tests. Mechanical allodynia was induced and maintained for up to 8 weeks after SNT in both male and female mice. Depressive- and anxiety-like behaviors were observed 8 weeks post-SNT injury regardless of sex. Chronic pain-induced cognitive deficits measured with the Morris water maze and novel object location test were seen only in male mice, not in female mice. Chronic neuropathic pain is accompanied by anxiety- and depressive-like behaviors in a mouse model regardless of sex, and male mice are more vulnerable than female mice to chronic pain-associated cognitive deficits.

中文翻译:

神经性疼痛小鼠模型中认知障碍的性别二态性

慢性疼痛易感性的性别差异是众所周知的。尽管最近的研究已经开始揭示神经损伤引起的疼痛敏化的性别依赖性机制,但尚未研究与慢性疼痛相关的情感和认知脑功能障碍的性别差异。因此,我们在小鼠神经性疼痛模型中测试了慢性疼痛是否会导致情感和认知障碍,以及这些障碍是否具有性别二态性。通过 L5 脊神经横断 (SNT) 损伤在雄性和雌性小鼠中诱导慢性神经性疼痛。疼痛敏感性通过von Frey测试测量。通过强迫游泳、悬尾和野外测试来评估抑郁和焦虑等情感行为。认知大脑功能通过莫里斯水迷宫和新物体定位和新物体识别测试进行评估。在雄性和雌性小鼠 SNT 后,机械性异常性疼痛被诱导并维持长达 8 周。无论性别如何,在 SNT 损伤后 8 周观察到抑郁和焦虑样行为。用莫里斯水迷宫和新物体定位测试测量的慢性疼痛引起的认知缺陷仅见于雄性小鼠,而不见于雌性小鼠。在小鼠模型中,无论性别如何,慢性神经性疼痛都伴随着类似焦虑和抑郁的行为,而且雄性小鼠比雌性小鼠更容易出现慢性疼痛相关的认知缺陷。无论性别如何,在 SNT 损伤后 8 周观察到抑郁和焦虑样行为。用莫里斯水迷宫和新物体定位测试测量的慢性疼痛引起的认知缺陷仅见于雄性小鼠,而不见于雌性小鼠。在小鼠模型中,无论性别如何,慢性神经性疼痛都伴随着类似焦虑和抑郁的行为,而且雄性小鼠比雌性小鼠更容易出现慢性疼痛相关的认知缺陷。无论性别如何,在 SNT 损伤后 8 周观察到抑郁和焦虑样行为。用莫里斯水迷宫和新物体定位测试测量的慢性疼痛引起的认知缺陷仅见于雄性小鼠,而不见于雌性小鼠。在小鼠模型中,无论性别如何,慢性神经性疼痛都伴随着类似焦虑和抑郁的行为,而且雄性小鼠比雌性小鼠更容易出现慢性疼痛相关的认知缺陷。
更新日期:2020-04-22
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