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Accelerated ovarian reserve depletion in female anti-Müllerian hormone knockout mice has no effect on lifetime fertility†
Biology of Reproduction ( IF 3.6 ) Pub Date : 2019-12-14 , DOI: 10.1093/biolre/ioz227
Ruikang Guo 1 , Michael W Pankhurst 1
Affiliation  

Anti-Müllerian hormone (AMH) inhibits the activation of primordial follicles in the ovary. This causes an increased rate of ovarian reserve depletion in Amh−/− mice. The depletion of the ovarian reserve is responsible for the onset of menopause but age-related infertility occurs in advance of ovarian reserve depletion. To determine whether accelerated loss of primordial follicles leads to earlier onset infertility, Amh−/− and Amh+/+ females were paired with Amh+/+ stud males and birth rates were recorded across the females’ reproductive lifespan. The number of primordial follicles remaining in the ovaries of Amh−/− and Amh+/+ females were quantified in two cohorts at 11–12 and 12–13 months of age. As expected, the ovarian reserve in the Amh−/− females became depleted approximately 1 month earlier than Amh+/+ females. However, no difference was observed in the cumulative number of births over the lifespan, nor were there any differences in mean littersize at any age. It is possible that the reproductive lifespan of mice is too short for sufficient divergence of primordial follicles numbers to cause differences in Amh−/− and Amh+/+ female fertility. An alternative explanation contradicts current thinking; the function of AMH may be unrelated to the longevity of the reproductive lifespan in female mice.

中文翻译:

雌性抗苗勒管激素敲除小鼠的卵巢储备消耗加速对终生生育能力没有影响†

抗苗勒管激素 (AMH) 抑制卵巢中原始卵泡的激活。这导致 Amh -/-小鼠的卵巢储备消耗率增加。卵巢储备耗尽是更年期开始的原因,但与年龄相关的不孕症发生在卵巢储备耗尽之前。为了确定原始卵泡的加速丢失是否会导致更早的不孕症,将 Amh -/-和 Amh +/+雌性与 Amh +/+ 种公雄性配对,并在雌性的整个生殖寿命中记录出生率。Amh -/-和 Amh +/+卵巢中剩余的原始卵泡数在 11-12 个月和 12-13 个月大的两个队列中对雌性进行了量化。正如预期的那样,Amh -/-女性的卵巢储备比 Amh +/+女性提前大约 1 个月耗尽。然而,在整个生命周期内的累积出生数量没有观察到差异,任何年龄的平均窝产仔数也没有任何差异。可能是因为小鼠的生殖寿命太短,原始卵泡数量的差异足以导致 Amh -/-和 Amh +/+雌性生育力的差异。另一种解释与当前的想法相矛盾;AMH 的功能可能与雌性小鼠生殖寿命的长短无关。
更新日期:2020-04-17
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