The brain is a metabolically demanding organ and its health directly depends on brain oxygen dynamics to prevent hypoxia and ischemia. Localized brain tissue oxygen is characterized by a baseline level combined with spontaneous oscillations. These oscillations are attributed to spontaneous changes of vascular tone at the level of arterioles and their frequencies depend on age. Specifically, lower frequencies are more typical for neonates than for adults. We have built a mathematical model which analyses the diffusion abilities of oxygen based on the frequency of source brain oxygen oscillations and neuronal demand. We have found that a lower frequency of spontaneous oscillations of localized brain tissue oxygen can support higher amplitudes of oxygen concentration at areas distant from a source relative to oscillations at higher frequencies. Since hypoxia and ischemia are very common events during early development and the neurovascular unit is underdeveloped in neonates, our results indicate that lower frequency oxygen oscillations can represent an effective passive method of neonatal brain protection against hypoxia. These results can have a potential impact on future studies aiming to find new treatment strategies for brain ischemia.

中文翻译：

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新生儿和成人脑组织氧的振荡和浓度动态。

大脑是需要代谢的器官，其健康直接取决于大脑的氧气动力学来防止缺氧和缺血。局部脑组织氧的特征是基线水平结合自发振荡。这些振荡归因于小动脉水平的血管紧张度的自发变化，其频率取决于年龄。具体而言，新生儿的频率比成人低。我们建立了一个数学模型，该模型根据源脑氧振荡的频率和神经元需求来分析氧的扩散能力。我们已经发现，相对于较高频率的振荡，局部脑组织氧的自发振荡的较低频率可以支持远离源的区域的氧气浓度更高的振幅。由于缺氧和局部缺血是早期发育中非常普遍的事件，而新生儿的神经血管单位发育不足，因此我们的结果表明，较低频率的氧气振荡可以代表一种有效的被动脑保护措施，以预防缺氧。这些结果可能对未来的研究产生潜在影响，这些研究旨在寻找脑缺血的新治疗策略。