Metabolomics (and exposomics) as disciplines provide an unprecedented opportunity to delve into the chemical space of our environmental health and pollution landscape in the most comprehensible and high throughput manner. Ranging from diet, drugs and medications, personal care and hygiene products, cosmetics, microbiome-derived chemicals, volatile organic carbons, breathe volatiles, gases, pollutants, metals, modified endogenous metabolites, and other industrial chemicals are all represented in this chemical ecosystem which we collectively call as exposures. Approaches such as innovations in sampling and sample preparation and extraction, to analytical instrumentation, computational strategies, and bioinformatic interrogation of the datasets, continue to explode in this hot area of research. Particularly, numerous high throughput and newly developed high resolution (HR)/accurate mass (AM)–mass-spectrometry (MS)-based platforms have begun to be instrumental in capturing this chemical space around us, be it volatiles, aerosols, synthetic chemicals, or dissolved organics, in the context of environmental health (i.e., pollution) and human health (and disease). In this review, I summarize the most recently developed, relevant, updated and important analytical platforms (from mass spectrometry to spectroscopy), informatics resources, tools, databases, and strategies in metabolomics research that hold promise as tool kits for exposomics research for superior understanding of human health and disease status.

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代谢组学工具研究污染与人类健康之间的联系

代谢组学（和外泌体组学）作为一门学科，为人们提供了前所未有的机会，可以以最易于理解和高通量的方式深入研究我们环境健康和污染状况的化学空间。从饮食，药物和药品，个人护理和卫生产品，化妆品，微生物组衍生的化学药品，挥发性有机碳，呼吸挥发物，气体，污染物，金属，改性的内源性代谢物和其他工业化学药品都可以在此化学生态系统中得到体现。我们统称为风险敞口。诸如采样，样品制备和提取，分析仪器，计算策略以及对数据集的生物信息学查询等方面的创新方法在这一研究热点中继续爆炸。尤其，众多的高通量和新开发的基于高分辨率（HR）/精确质量（AM）-质谱（MS）的平台已开始在捕获我们周围的此化学空间（包括挥发物，气溶胶，合成化学物质或在环境健康（即污染）和人类健康（和疾病）的背景下溶解有机物。在这篇综述中，我总结了代谢组学研究中最新开发，相关，更新和重要的分析平台（从质谱学到光谱学），信息学资源，工具，数据库和策略，它们有望作为用于深入研究的组学研究工具包人类健康和疾病状况。