There has been a traditional conceptual partition between the so-called non-lesional genetic epilepsies and the genetically determined interposed epileptogenic structural abnormalities. In this review, we summarise how growing evidence acquired through neuroimaging and neurobiology modelling is demonstrating that a distinction between lesional and functional (or non-lesional) epileptogenesis is less obvious than previously thought, particularly for epileptogenic neurodevelopmental disorders, but also for most genetically determined epilepsies.

中文翻译：

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损伤性和非损伤性癫痫：模糊的遗传边界

在所谓的非损伤性遗传性癫痫和由遗传决定的介入性癫痫结构异常之间存在传统的概念划分。在这篇综述中，我们总结了通过神经影像学和神经生物学建模获得的越来越多的证据表明，损伤性和功能性（或非损伤性）癫痫发生之间的区别没有以前认为的那么明显，特别是对于癫痫源性神经发育障碍，但对于大多数基因决定的癫痫。