The World Health Organization (WHO) recently updated the diagnostic criteria for serrated polyposis syndrome (SPS). One of the three previous diagnostic criteria (criterion II²⁰¹⁰) is now abandoned: ≥ 1 serrated polyp (SP) proximal to the sigmoid in a first-degree relative (FDR) of a patient with SPS. Individuals fulfilling this abandoned criterion now receive the same surveillance recommendations as all FDRs of patients with SPS. We aimed to compare the incidence of advanced neoplasia (AN) in FDRs with vs. without fulfillment of the abandoned criterion II²⁰¹⁰. We retrospectively recruited FDRs of patients with SPS who underwent a colonoscopy, and stratified them according to fulfilment of criterion II²⁰¹⁰ at baseline. Our primary and secondary outcomes were AN incidence during surveillance and at baseline, respectively. We included 224 FDRs of patients with SPS, of whom 36 (16%) fulfilled criterion II²⁰¹⁰ at baseline. One hundred and five underwent surveillance after baseline. Criterion II²⁰¹⁰-positive FDRs were at increased risk of AN, both during surveillance (hazard ratio 8.94, 95% CI 2.15–37.1, p = .003) as well as at baseline (adjusted odds-ratio 9.30, 95% CI 3.7–23.3, p < .001). FDRs of patients with SPS that underwent colonoscopy and fulfilled the abandoned criterion II²⁰¹⁰ for SPS diagnosis were at increased risk of AN at baseline and during surveillance in this small, retrospective cohort study. Our results should be interpreted with caution but suggest that adherence to surveillance recommendations for all FDRs of patients with SPS is important, especially for those that would have fulfilled the now abandoned criterion II²⁰¹⁰.

中文翻译：

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舍弃性标准II对锯齿状息肉病综合征的诊断的（ir）相关性：一项回顾性队列研究。

世界卫生组织（WHO）最近更新了锯齿状息肉病综合征（SPS）的诊断标准。现在已放弃了之前的三个诊断标准之一（标准II ²⁰¹⁰）：SPS患者的一级亲属（FDR）中，在乙状结肠附近的锯齿状息肉（SP）≥1。现在，满足此废弃标准的个人将获得与SPS患者的所有FDR相同的监测建议。我们的目的是比较符合或不符合废弃标准II ^2010的FDR中晚期肿瘤形成（AN）的发生率。我们回顾性地收集了接受结肠镜检查的SPS患者的FDR，并根据标准II ^{2010的要求}对其进行分层。在基线。我们的主要和次要结局分别是监测期间和基线时的AN发生率。我们包括224个一级亲属的患者SPS，其中36（16％）符合标准II ²⁰¹⁰基线。基线后对一百零五进行了监视。在监测期间（危险比8.94，95％CI 2.15–37.1，p = .003）以及基线（校正比值比9.30，9.3％，95％CI 3.7 –），^2010年第二标准的FDR患AN的风险均增加。 23.3，p <.001）。患者的一级亲属与SPS了经历了结肠镜检查，并履行废弃的标准II ²⁰¹⁰在这项小型回顾性队列研究中，用于SPS诊断的患者在基线和监测期间发生AN的风险增加。我们的研究结果应该谨慎解释，但建议遵守监督建议患者所有一级亲属与SPS是很重要的，特别是对那些可能已经实现了，现在放弃了标准II ²⁰¹⁰。