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Oral microbiota and autism spectrum disorder (ASD)
Journal of Oral Microbiology ( IF 4.5 ) Pub Date : 2019-12-12 , DOI: 10.1080/20002297.2019.1702806
Ingar Olsen 1 , Steven D Hicks 2
Affiliation  

ABSTRACT

Autism spectrum disorder (ASD) is associated with several oropharyngeal abnormalities, including dysbiosis in the oral microbiota. Since the oral cavity is the start of the gastrointestinal tract, this strengthens and extends the notion of a microbial gut-brain axis in ASD and even raises the question whether a microbial oral-brain axis exists. It is clear that oral bacteria can find their way to the brain through a number of pathways following routine dental procedures. A connection between the oral microbiota and a number of other brain disorders has been reported. As the evidence so far for an association between the oral microbiota and ASDs rests on a few reports only, further studies in this field are necessary. The current review discusses a possible relationship between oral bacteria and the biologic and symptomologic aspects of ASD, focusing on the clinical implications for diagnostic and therapeutic development.



中文翻译:

口腔微生物群与自闭症谱系障碍 (ASD)

摘要

自闭症谱系障碍 (ASD) 与多种口咽异常有关,包括口腔微生物群失调。由于口腔是胃肠道的起点,这加强和扩展了 ASD 中微生物肠-脑轴的概念,甚至提出了微生物口-脑轴是否存在的问题。很明显,口腔细菌可以通过常规牙科手术后的多种途径进入大脑。据报道,口腔微生物群与许多其他脑部疾病之间存在联系。由于迄今为止口腔微生物群与 ASD 之间关联的证据仅基于少数报告,因此有必要对该领域进行进一步研究。当前的审查讨论了口腔细菌与 ASD 的生物学和症状学方面之间的可能关系,

更新日期:2020-04-20
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