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Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption
Beni-Suef University Journal of Basic and Applied Sciences Pub Date : 2019-12-01 , DOI: 10.1186/s43088-019-0025-9
Ayat S. Rashwan , Marwa A. El-Beltagy , Sherif Y. Saleh , Ibrahim A. Ibrahim

One of the serious public health problems in the world is metabolic syndrome. It includes visceral obesity, dyslipidemia, insulin resistance, hyperglycemia, and hypertension. As a contributor to almost all the classic signs of metabolic syndrome, fructose was the ideal choice. There are certain shortcomings with existing drugs for insulin-resistant treatment. Plants still represent the main source of most available medicines. Cinnamaldehyde (CNA) is an active principle of Cinnamomum zeylanicum. Costunolide (CE) is natural sesquiterpene lactones, which is the main bioactive constituent of Saussurea lappa. The main aim of the present study is to investigate the effect of the synthetic antidiabetic agent (metformin) in comparison with natural constituents (cinnamaldehyde, costunolide) after developing a reliable model for insulin resistance by using high fructose diet (HFD). It was found that HFD increased plasma glucose, insulin, glycosylated hemoglobin, HbA1c, serum total cholesterol, LDL-cholesterol, triglyceride, ALT, AST, creatinine, and uric acid. Moreover, HFD decreased hepatic reduced glutathione and superoxide dismutase levels. While oral administration of cinnamaldehyde and costunolide significantly decreased plasma glucose, HbA1c, total cholesterol, LDL-cholesterol, triglyceride, and increased level of hepatic reduced glutathione and superoxide dismutase activity. Also, cinnamaldehyde and costunolide restored the altered plasma levels of ALT, AST, creatinine, and uric acid to normal. The results of this experimental study showed that cinnamaldehyde and costunolide could be used as safe drugs for treating different abnormalities of metabolic syndrome.

中文翻译:

肉桂醛和木香内酯对抗果糖摄入过多引起的代谢综合征的潜在作用

世界上严重的公共卫生问题之一是代谢综合征。它包括内脏肥胖、血脂异常、胰岛素抵抗、高血糖和高血压。作为几乎所有代谢综合征典型症状的促成因素,果糖是理想的选择。现有的胰岛素抵抗治疗药物存在某些缺陷。植物仍然是大多数可用药物的主要来源。肉桂醛 (CNA) 是 Cinnamomum zeylanicum 的活性成分。Costunolide (CE) 是天然倍半萜内酯,是雪莲的主要生物活性成分。本研究的主要目的是研究合成抗糖尿病药物(二甲双胍)与天然成分(肉桂醛、通过使用高果糖饮食 (HFD) 开发出可靠的胰岛素抵抗模型后,木香内酯)。发现 HFD 增加了血浆葡萄糖、胰岛素、糖化血红蛋白、HbA1c、血清总胆固醇、低密度脂蛋白胆固醇、甘油三酯、ALT、AST、肌酐和尿酸。此外,HFD 降低了肝脏还原型谷胱甘肽和超氧化物歧化酶水平。虽然口服肉桂醛和木香内酯可显着降低血浆葡萄糖、HbA1c、总胆固醇、低密度脂蛋白胆固醇、甘油三酯,并增加肝脏降低的谷胱甘肽和超氧化物歧化酶活性。此外,肉桂醛和木香内酯使 ALT、AST、肌酐和尿酸的血浆水平恢复正常。
更新日期:2019-12-01
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