Many attempts have been conducted for green synthesis of biofunctional scaffolds and implant coatings. Hydroxyapatite Ca₅(OH)(PO₄)₃ (HA), is an excellent material for these purposes. HA is a major mineral component of vertebrate bones and teeth; it constitutes 70 wt% of human bones. This paper reports on the sustainable fabrication of HA particles in different morphologies including nanoplates (400 nm L and 150 nm W), and nanorods (10 nm D and 500 nm L). XRD diffractogram revealed highly crystalline structure. HA nanoplates were surface modified with poly(ethylene-co-AA) polymeric surfactant; organic modified HA nanoplates demonstrated complete change in surface properties from hydrophilic to hydrophobic. It demonstrated effective phase transfer from aqueous phase to organic phase, with decrease in nanoplate size to 100 nm L, 50 nm W. Layered HA plates were further developed via surface modification with dodecanedioic acid; this approach can offer laminated or exfoliated plates for effective integration into bio-compatible polymers. This manuscript shaded the light on facile green synthesis of HA nanoparticles with controlled morphology and surface properties.

中文翻译：

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形态和表面特性可控的羟基磷灰石纳米粒子的绿色合成生物医学应用。

已经进行了许多尝试来绿色合成生物功能支架和植入物涂层。羟基磷灰石Ca ₅（OH）（PO ₄）₃（HA）是用于这些目的的出色材料。HA是脊椎动物骨骼和牙齿的主要矿物质成分；它占人体骨骼的70 wt％。本文报道了可持续制造具有不同形态的HA颗粒的情况，包括纳米板（400 nm L和150 nm W）和纳米棒（10 nm D和500 nm L）。XRD衍射图显示高度结晶的结构。HA纳米板用聚（乙烯-co-AA）聚合物表面活性剂进行了表面改性；有机改性的HA纳米板显示出表面性能从亲水性到疏水性的完全变化。它证明了从水相到有机相的有效相转移，纳米板尺寸减小到100 nm L，50 nmW。通过用十二烷二酸进行表面改性，进一步开发了层状HA板；这种方法可以提供层压板或剥离板，以有效整合到生物相容性聚合物中。该手稿为形态和表面特性可控的HA纳米粒子的绿色合成提供了便利。