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Methane and Inflammation - A Review (Fight Fire with Fire)
Intensive Care Medicine Experimental Pub Date : 2019-12-01 , DOI: 10.1186/s40635-019-0278-6
Marietta Zita Poles 1 , László Juhász 1 , Mihály Boros 1
Affiliation  

Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally considered to be biologically inactive. However, recent studies have provided evidence for methane bioactivity in various in vivo settings. The administration of methane either in gas form or solutions has been shown to have anti-inflammatory and neuroprotective effects in an array of experimental conditions, such as ischemia/reperfusion, endotoxemia and sepsis. It has also been demonstrated that exogenous methane influences the key regulatory mechanisms and cellular signalling pathways involved in oxidative and nitrosative stress responses. This review offers an insight into the latest findings on the multi-faceted organ protective activity of exogenous methane treatments with special emphasis on its versatile effects demonstrated in sepsis models.

中文翻译:

甲烷和炎症 - 评论(以火扑灭)

哺乳动物产甲烷被认为是厌氧胃肠道菌群碳水化合物发酵的指标。一旦由微生物产生或由非细菌过程释放,甲烷通常被认为是无生物活性的。然而,最近的研究为甲烷在各种体内环境中的生物活性提供了证据。以气体形式或溶液形式施用甲烷已被证明在一系列实验条件下具有抗炎和神经保护作用,例如缺血/再灌注、内毒素血症和败血症。还证明外源甲烷影响氧化和亚硝化应激反应中涉及的关键调节机制和细胞信号通路。
更新日期:2019-12-01
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