Annual Review of Animal Biosciences ( IF 12.0 ) Pub Date : 2020-02-18 , DOI: 10.1146/annurev-animal-021419-083720 Yi Sun 1 , Tian Huang 2 , Lennart Hammarström 3 , Yaofeng Zhao 4
Immunoglobulins (Igs), as one of the hallmarks of adaptive immunity, first arose approximately 500 million years ago with the emergence of jawed vertebrates. Two events stand out in the evolutionary history of Igs from cartilaginous fish to mammals: (a) the diversification of Ig heavy chain (IgH) genes, resulting in Ig isotypes or subclasses associated with novel functions, and (b) the diversification of genetic and structural strategies, leading to the creation of the antibody repertoire we know today. This review first gives an overview of the IgH isotypes identified in jawed vertebrates to date and then highlights the implications or applications of five new recent discoveries arising from comparative studies of Igs derived from different vertebrate species.
中文翻译:
免疫球蛋白:新见解,意义和应用
免疫球蛋白(Igs)作为适应性免疫的标志之一,大约在5亿年前出现于有颌脊椎动物的出现。从软骨鱼类到哺乳动物的Igs进化史上突出了两个事件:(a)Ig重链(IgH)基因的多样化,导致与新功能相关的Ig同种型或亚类,以及(b)遗传和遗传多样性结构策略,导致我们今天知道的抗体库的创建。这篇综述首先概述了迄今为止在颌骨脊椎动物中鉴定出的IgH同种型,然后重点介绍了来自不同脊椎动物物种的Ig的比较研究中产生的五个最新发现的意义或应用。