OBJECTIVE To prospectively evaluate the effect of PSA- and VIM DBS on speech in ET patients. METHODS Leads were implanted bilaterally with contacts placed in both VIM and PSA. Thirteen patients were analyzed pre- and postoperatively. Preoperative speech of ET patients was compared to healthy controls. PSA- and VIM-DBS were evaluated in a randomized, double-blind crossover phase. RESULTS At preoperative baseline, we found reduced intelligibility. Differences in acoustic and VAS data ('ability to speak') compared to controls were gradient. Articulation rate could be predicted by disease duration. Decreased articulation rate, spirantization and voicing were found for PSA- and VIM-DBS. Targets did not differ in terms of speech deterioration. CONCLUSION Speech in ET patients without DBS can be impaired, dependent on patient's individual characteristics. Both PSA- and VIM-DBS affect speech in a comparable way. Thus, the PSA can be considered an alternative DBS target in ET without higher risk of dysarthria.

中文翻译：

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丘脑和后丘脑深部脑刺激对特发性震颤患者言语的影响——一项前瞻性、随机、双盲交叉研究

目的 前瞻性评价 PSA-和 VIM DBS 对 ET 患者言语的影响。方法 双侧植入导线，触点放置在 VIM 和 PSA 中。对 13 名患者进行了术前和术后分析。将 ET 患者的术前言语与健康对照进行比较。PSA- 和 VIM-DBS 在随机、双盲交叉阶段进行评估。结果 在术前基线，我们发现可懂度降低。与对照相比，声学和 VAS 数据（“说话能力”）的差异是梯度的。可以通过疾病持续时间预测关节率。发现 PSA- 和 VIM-DBS 的发音速度、旋转和发声降低。目标在言语恶化方面没有差异。结论 没有 DBS 的 ET 患者的语音可能会受损，这取决于患者的 s 个人特点。PSA- 和 VIM-DBS 都以类似的方式影响语音。因此，PSA 可被视为 ET 中的替代 DBS 目标，而不会增加构音障碍的风险。