Several reports have shown the presence of P2 receptors in hematopoietic stem cells (HSCs). These receptors are activated by extracellular nucleotides released from different sources. In the hematopoietic niche, the release of purines and pyrimidines in the milieu by lytic and nonlytic mechanisms has been described. The expression of P2 receptors from HSCs until maturity is still intriguing scientists. Several reports have shown the participation of P2 receptors in events associated with modulation of the immune system, but their participation in other physiological processes is under investigation. The presence of P2 receptors in HSCs and their ability to modulate this population have awakened interest in exploring the involvement of P2 receptors in hematopoiesis and their participation in hematopoietic disorders. Among the P2 receptors, the receptor P2X7 is of particular interest, because of its different roles in hematopoietic cells (e.g., infection, inflammation, cell death and survival, leukemias and lymphomas), making the P2X7 receptor a promising pharmacological target. Additionally, the role of P2Y12 receptor in platelet activation has been well-documented and is the main example of the importance of the pharmacological modulation of P2 receptor activity. In this review, we focus on the role of P2 receptors in the hematopoietic system, addressing these receptors as potential pharmacological targets.

中文翻译：

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P2 受体参与造血和造血障碍，并作为药理学靶点。

一些报告表明造血干细胞 (HSC) 中存在 P2 受体。这些受体被不同来源释放的细胞外核苷酸激活。在造血生态位中，已经描述了通过溶解和非溶解机制在环境中释放嘌呤和嘧啶。HSC 直至成熟期间 P2 受体的表达仍然令科学家们着迷。一些报告表明 P2 受体参与与免疫系统调节相关的事件，但它们对其他生理过程的参与仍在研究中。HSC 中 P2 受体的存在及其调节该群体的能力引起了人们对探索 P2 受体参与造血及其参与造血疾病的兴趣。在P2受体中，受体P2X7特别令人感兴趣，因为它在造血细胞中具有不同的作用（例如，感染、炎症、细胞死亡和存活、白血病和淋巴瘤），使得P2X7受体成为有前途的药理学靶点。此外，P2Y12 受体在血小板活化中的作用已得到充分证明，并且是 P2 受体活性药理调节重要性的主要例子。在这篇综述中，我们重点关注 P2 受体在造血系统中的作用，将这些受体作为潜在的药理学靶点。