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High 2,3-butanediol production from glycerol by Raoultella terrigena CECT 4519
Bioprocess and Biosystems Engineering ( IF 3.8 ) Pub Date : 2019-12-17 , DOI: 10.1007/s00449-019-02266-8
Vanessa Ripoll 1 , Alberto Rodríguez 2 , Miguel Ladero 3 , Victoria E Santos 3
Affiliation  

Abstract

Bioconversion of biodiesel-derived glycerol into 2,3-butanediol has received recently much attention due to its increasing surplus and its multiple uses in industry as bulk chemical. The influence of initial glycerol concentration on 2,3-butanediol production in batch runs has been studied. A concentration higher than 140 g/L produces an inhibitory effect on the final 2,3-butanediol concentration and its production rate. In batch mode, the highest yield respect to the theoretical maximum yield (71%) was reached employing 140 g/L as initial concentration 140 g/L. Based on these results, a high 2,3-butanediol production has been achieved through a fed-batch strategy. The reached 2,3-butanediol concentration was 90.5 g/L from pure glycerol and 80.5 g/L from raw glycerol. The 2,3-butanediol yield respect to the theoretical maximum yield was also improved through the fed-batch operation (90%). To date, this concentration is the highest produced amount employing as biocatalyst a non-pathogenic bacterium (level 1).



中文翻译:

特劳根菌CECT 4519从甘油中高产2,3-丁二醇

摘要

生物柴油衍生的甘油向2,3-丁二醇的生物转化最近受到了广泛的关注,因为它的剩余量不断增加,并且在工业中作为大宗化学品被广泛使用。研究了初始甘油浓度对分批运行中2,3-丁二醇生产的影响。高于140 g / L的浓度会对最终的2,3-丁二醇浓度及其生产率产生抑制作用。在分批模式下,使用140 g / L作为初始浓度140 g / L,可以达到相对于理论最大产率的最高产率(71%)。基于这些结果,通过分批补料策略已实现了高2,3丁二醇生产。从纯甘油中达到的2,3-丁二醇浓度为90.5 g / L,从粗甘油中达到80.5 g / L。2 通过补料分批操作,相对于理论最大产率的3-丁二醇产率也得到了提高(90%)。迄今为止,该浓度是采用非病原性细菌作为生物催化剂的最高产量(1级)。

更新日期:2020-03-20
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