Abstract

A couple of new cycloheximide epimers, 13(α)-acetoxy-anhydroisoheximide (1) and 13(β)-acetoxy-anhydroisoheximide (2), together with six known compounds (3–8), were obtained from the cultures of Streptomyces sp. YG7. The structures were elucidated based on a comprehensive spectroscopic data analysis including 1D and 2D NMR, as well as HRESIMS, and by comparison with the literature. The X-ray crystal analysis of 1 further confirmed the structure. All the compounds were tested for antifungal activity. Compounds 1, 2 and 5–8 showed moderate Canidia albicans inhibitory activity, while 5 and 6 presented moderate Pyricularia oryzae inhibitory activity.

摘要

两个新的放线菌酮差向异构体，13（α） -乙酰氧基anhydroisoheximide（1）和13（β） -乙酰氧基anhydroisoheximide（2具有六个已知化合物（3），一起- 8），是从链霉菌的培养物中获得。YG7。根据全面的光谱数据分析（包括1D和2D NMR以及HRESIMS），并与文献进行比较，阐明了结构。1的X射线晶体分析进一步证实了该结构。测试所有化合物的抗真菌活性。化合物1、2和5-8显示中等的白色念珠菌抑制活性，而化合物5和6显示中等的稻瘟病菌的抑制活性。