Citrus represents the most important non-climacteric fruits and thus understanding transcriptional control during fruit development is important for improving fruit yield and quality. Compared to relatively intensive transcriptomic studies of ripening citrus fruits, much less is known regarding expanding fruits. To provide a systems view of hormone response and transcriptional regulation in citrus fruit development from Stage I (slow fruit growth) to Stage II (rapid growth), we re-analyzed the fruit transcriptomes which we previously collected from the sweet orange varieties, Newhall, Xinhui, Bingtang, and Succari (Citrus sinensis L. Osbeck). A total of 3145 genes were differentially expressed across all four varieties, indicating that they likely have conserved functions in orange fruit development. Using a gene coexpression network-based systems approach, we constructed the subnetworks respectively for gibberellin response, ethylene response, transcription factors and chromatin modifications. Analysis of these subnetworks has led to the identification of more than a dozen major hub genes, such as EXPA1, GASA1/14, ERF13, HB22, ATK1, and TOPII, which represent the most promising candidates for future functional characterization.

中文翻译：

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在四个甜橙品种中差异表达基因的网络分析揭示了赤霉素和乙烯响应及转录调控在柑桔类水果中的保守作用

柑橘代表了最重要的非更年期水果，因此了解水果发育过程中的转录控制对于提高水果产量和品质至关重要。与成熟柑橘类水果的相对深入的转录组学研究相比，关于膨大水果的信息知之甚少。为了提供从第一阶段（缓慢的水果生长）到第二阶段（快速的生长）的柑橘类水果发育过程中激素反应和转录调控的系统视图，我们重新分析了先前从甜橙品种Newhall收集的水果转录组。新会，冰糖和苏打（柑橘）L.Osbeck）。共有3145个基因在所有四个品种中差异表达，表明它们可能在橙色水果发育中具有保守的功能。使用基于基因共表达网络的系统方法，我们分别构建了赤霉素响应，乙烯响应，转录因子和染色质修饰的子网。这些子网的分析已导致十几主要枢纽基因，如识别EXPA1，GASA1 / 14，ERF13，HB22，ATK1和TOPII，这代表了未来的功能特性最有希望的候选人。