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Biologically Benign Multi-functional Mesoporous Silica Encapsulated Gold/Silver Nanorods for Anti-bacterial Applications by On-demand Release of Silver Ions
BioChip Journal ( IF 4.3 ) Pub Date : 2019-12-06 , DOI: 10.1007/s13206-019-3407-0
Seokyoung Yoon , Younghwan Chung , Jin Woong Lee , Junhyuck Chang , Jeon Geon Han , Jung Heon Lee

Although silver (Ag)-based nanoparticles (NPs) are frequently used for bactericidal purposes, they have critical issues including excessive release of Ag+, severe oxidation, and cytotoxicity. In this study, we designed a multifunctional, on-demand antibacterial agent by successively encapsulating bimetallic gold/silver nanorods (Ag/AgNRs) with mesoporous silica (mSiO2) shells. Au/AuNRs were synthesized by coating Ag on AuNRs in a controlled manner, so that they exhibited a localized surface plasmon resonance peak in the near-infrared (NIR) region. When Au/AgNR@mSiO2 NPs were irradiated with an NIR laser under optimal conditions (0.4 W/cm2), they generated a small amount of heat (40–45 oC), which successively triggered the release of Ag+ and induced bacterial cell death. Here, mSiO2 shells play critical roles because they not only protect Ag from oxidation but also prevent the burst release of Ag+ and improve biocompatibility of the antibacterial agent against normal cells. We found that this multifunctional bacterial agent effectively kills gram-negative Escherichia coli and gram-positive Staphylococcus aureus without significantly increasing the temperature of the medium. Au/AgNR@mSiO2 NPs were also biologically benign with high biocompatibility against mammalian cells.

中文翻译:

通过按需释放银离子对细菌应用的生物良性多功能介孔二氧化硅封装的金/银纳米棒

尽管基于银(Ag)的纳米颗粒(NPs)经常用于杀菌目的,但它们具有严重的问题,包括过量释放Ag +,严重氧化和细胞毒性。在这项研究中,我们通过用介孔二氧化硅(mSiO 2)外壳依次包封双金属金/银纳米棒(Ag / AgNRs),设计了一种多功能按需抗菌剂。通过以受控方式将Ag涂覆在AuNRs上来合成Au / AuNRs,从而使它们在近红外(NIR)区域中表现出局部表面等离子体共振峰。当在最佳条件下(0.4 W / cm 2)用NIR激光辐照Au / AgNR @ mSiO 2 NP时,它们会产生少量热量(40–45 oC),随后触发了Ag +的释放并诱导细菌细胞死亡。在这里,mSiO 2壳起着至关重要的作用,因为它们不仅可以保护Ag免受氧化,还可以防止Ag +的突然释放,并提高抗菌剂对正常细胞的生物相容性。我们发现这种多功能细菌剂可有效杀死革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌,而不会显着提高培养基温度。Au / AgNR @ mSiO 2 NPs在生物学上也是良性的,对哺乳动物细胞具有高生物相容性。
更新日期:2019-12-06
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