Abstract

Synchronization is a widely studied phenomenon in neuroscience. The ever-increasing morbidity of brain diseases makes the investigation on this topic significant in both psychology and medicine. In this paper, we consider an Izhikevich neuronal network composed of both excitatory and inhibitory neurons, and introduce the Tsodyks-Uziel-Markram (TUM) model of neuronal transmission. To study the impact of inhibitory neurons in the synchronization, we make comparative studies by considering the inhibitory neurons could fire either spontaneously or not in the network. Simulation results exemplify that the synchronized system shows different periodic-like oscillatory patterns of multi-stripes. We find that the inhibitory neurons have two-fold impacts on the oscillatory patterns. On the one hand, they can delay the firing of the neurons, deleterious for synchronization. On the other hand, they are able to facilitate the transition of the oscillatory patterns, beneficial for synchronization.

Graphical abstract

中文翻译：

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抑制性神经元对Izhikevich神经元网络同步化的双重影响

摘要

同步是神经科学中广泛研究的现象。脑疾病的发病率不断增加，使得对该主题的研究在心理学和医学上均具有重要意义。在本文中，我们考虑了由兴奋性神经元和抑制​​性神经元组成的Izhikevich神经元网络，并介绍了神经元传播的Tsodyks-Uziel-Markram（TUM）模型。为了研究抑制性神经元在同步中的影响，我们通过考虑抑制性神经元在网络中是否自发触发进行比较研究。仿真结果表明，该同步系统显示出不同的周期性的多条纹振荡模式。我们发现抑制性神经元对振荡模式有两方面的影响。一方面，它们可以延迟神经元的发射，有害于同步。另一方面，它们能够促进振荡模式的转变，有利于同步。

图形概要