The aim of this study was to elaborate a suitable hydrogel to be used as drug carrier for antileishmanial treatment. Therefore, a PVP hydrogel was synthesized using gamma radiation technique. In the first step, PVP, agar and PEG concentrations were modified as a function of dose rate. Then, established polymers were characterized using FTIR, solid-state 13 C NMR and TGA analyses. After that, rheological measurements followed to determine elastic and viscous modulus. Based on these techniques, it was found that synthesized PVP–hydrogels have the structure of a semi-interpenetrated network (SIPN). The sample containing 3% of PEG was selected to test its potential as antileishmanial drug carrier because it had the elastic modulus that fits more the application as wound dressing. As antileishmanial drug carrier, it has been shown that in the presence of hydrogel, the activity of conventional drug (Amphotericin B) on Leishmania promastigotes was markedly improved with an increase in selectivity index from 10.54 to 56.8.

中文翻译：

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辐射交联 PVP 水凝胶的合成和表征及其作为抗利什曼药物载体的潜力研究

本研究的目的是精心设计一种合适的水凝胶，用作抗利什曼病治疗的药物载体。因此，使用伽马辐射技术合成了 PVP 水凝胶。在第一步中，PVP、琼脂和 PEG 浓度被修改为剂量率的函数。然后，使用 FTIR、固态 13 C NMR 和 TGA 分析表征已建立的聚合物。之后，进行流变测量以确定弹性和粘性模量。基于这些技术，发现合成的 PVP-水凝胶具有半互穿网络（SIPN）的结构。选择含有 3% PEG 的样品来测试其作为抗利什曼病药物载体的潜力，因为它的弹性模量更适合作为伤口敷料的应用。作为抗利什曼药物载体，