Vesicular trafficking between endoplasmic reticulum and Golgi plays a major role in the growth and proliferation of breast cancer cells. Various proteins regulate this ER-Golgi kinetics; however, their potential as therapeutic targets in breast cancer has not been much evaluated. In the present review, we try to shed light on the implication of vesicular trafficking–related proteins like Rab family of proteins, in the pathogenesis of breast cancer via promoting cancer cell proliferation and invasion. The literature for this review was mainly searched in PubMed during the years 2014 to 2018 by using the keywords, ‘breast cancer’, ‘breast cancer and its current treatments’, ‘breast cancer and vesicular trafficking’, ‘Rab family proteins in breast cancer’, etc. Targeting proteins involved in vesicular transport like Rab GTPases, the neural precursor cell–expressed developmentally downregulated protein 9 (NEDD9), runt-related transcription factor 2 (RUNX2), human rhomboid family-1 (RHBDF1), monocarboxylate transporter 4, etc., would aid in designing improved therapeutics for the treatment of breast cancer.

中文翻译：

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囊泡运输相关蛋白作为乳腺癌的潜在治疗靶点

内质网和高尔基体之间的囊泡运输在乳腺癌细胞的生长和增殖中起主要作用。各种蛋白质调节这种 ER-高尔基体动力学；然而，它们作为乳腺癌治疗靶点的潜力尚未得到太多评估。在本综述中，我们试图通过促进癌细胞增殖和侵袭来阐明与囊泡运输相关的蛋白质（如 Rab 蛋白家族）在乳腺癌发病机制中的意义。本综述的文献主要在 2014 年至 2018 年期间在 PubMed 中使用关键词“乳腺癌”、“乳腺癌及其当前治疗”、“乳腺癌和囊泡运输”、“乳腺癌中的 Rab 家族蛋白”进行检索。 '等。靶向参与囊泡运输的蛋白质，如 Rab GTPases，